在有轻度和中度肝受损受试者(Child-Pugh类型A和B)当与健康匹配对照受试者比较,单剂量给予10 mg dapagliflozin后dapagliflozin的均数Cmax和AUC分别至较高至12%和36%。这些差别不认为有临床上意义。在有严重肝受损患者中(Child-Pugh类别C)当与健康匹配对照比较时,dapagliflozin的均数Cmax和AUC分别较高至40%和67%[见...
AHA 2022上公布的最新研究数据显示:基线肾功能情况并不能改变达格列净对射血分数轻度降低或保留型心衰患者的获益。虽然达格列净没有显著降低肾脏复合结局的发生率,但是总体事件发生率是低的。与安慰剂相比,达格列净延缓了eGFR的下降速度。 ...
英文名称 Dapagliflozin 储存方法 -20℃,干燥、避光、密封 货源 厂家直销 是否现货 是 纯度 HPLC≥98% 包装 西林瓶 保质期 2年 可售卖地 全国 等级 分析纯AR 货号 WKQ-0020644 价格说明 价格:商品在爱采购的展示标价,具体的成交价格可能因商品参加活动等情况发生变化,也可能随着购买数量不同或所选...
产品活性:Dapagliflozin impurity A (Compound A)是达格列净过氧化物,基因毒性杂质,在很低浓度时即可造成人体遗传物质的损伤,进而导致基因突变并可能促使肿瘤发生。 生物活性:达格列净杂质A(化合物A)是达格列净过氧化物,是一种遗传毒性杂质,在极低浓度下即可对人类遗传物质造成损害,导致基因突变,甚至可能导致肿瘤[1...
Dapagliflozin amorphous & propanediol > Cryogenic process > Green Chemistry EU DMF US DMF Korean DMF Canadian DMF ...
A. Ranganath Rights and permissions Reprints and permissions About this article Cite this article Saleh, S., Hanna, G., El-Nabi, S.H. et al. Dapagliflozin, a sodium glucose cotransporter 2 inhibitors, protects cardiovascular function in type-2 diabetic murine model. J Genet 99, 46 (2020)....
B.卡格列净(Canagliflozin);达格列净(Dapagliflozin);伊普拉列净(Ipragliflozin);伊普拉列净Ipragliflozin)C.达格列净(Dapagliflozin);恩格列净(Empagliflozin);伊普拉列净(Ipragliflozin);妥格列净(Tofogliflozin) A.卡格列净(Canagliflozin);达格列净(Dapagliflozin);B.卡格列净(Canagliflozin);达格列净(Dapagliflozin);...
Dapagliflozin reduced the primary composite end point compared to placebo in participants with HFimpEF (HR = 0.74, 95% CI = 0.56–0.97) to a similar extent as patients with LVEF consistently over 40% (HR = 0.84, 95% CI 0.73–0.95; interactionP = 0.43) (Fig.2a,b)....
Whether the sodium–glucose cotransporter 2 inhibitor dapagliflozin reduces the risk of a range of morbidity and mortality outcomes in patients with heart failure regardless of ejection fraction is unknown. A patient-level pooled meta-analysis of two tri
(15.1 ± 2.3 years), and 63 patients in toxicological series. The effect of dapagliflozin and empagliflozin in T2DM was demonstrated by HbA1c reduction in two randomised trials among a total of 177 adolescents, with a mean HbA1c difference of -0.82% (95% confidence interval -1.34 to -0.29)...