这些被Walter Land于2003年称为损害相关分子模式(DAMP)。尽管危险理论引起了人们的极大热情,并且在过去的20年中引发了许多争议,但现在人们已经广泛接受PAMP和DAMP都可以通过激活经典PRR(不仅包括TLR)来启动免疫反应。而且还有其他的感应受体,例如...
它通过模式识别受体(pattern recognition receptor, PRR)识别具有病原体相关分子模式(pathogen associated molecular pattern, PAMP)或损伤相关分子模式(damage associated molecular pattern, DAMP)的生物大分子。PAMP包括病原体入侵所带来的一系列生物大分子,如细菌表面的脂多糖(lipopolysaccharide, LPS)、鞭毛、病毒入侵带来...
PAMP和DAMP也被称为固有免疫原。 1.PAMP:为进化保守的微生物基本结构及成分,如革兰氏阴性菌的脂多糖(lipopolysaccharide,LPS)、革兰氏阳性菌的脂磷壁酸(lipoteichoic acid,LTA)和肽聚糖(pepti-doglycan,PGN)、微生物细胞壁的成分甘露...
cause direct cellular damage and/or trigger an immune response in the host often leading to excessive cytokine production, a maladaptive systemic inflammatory response syndrome response (SIRS), and tissue damage that releases DAMPs, such as activated complement and HMGB-1, into the bloodstream causing...
2012. The origin and properties of extracellular DNA: From PAMP to DAMP. Clinical Immunology 144(1): 32–40. : 10.1016/j.clim.2012.04.006 . CentralPisetsky DS (2012) The origin and properties of extracellular DNA: from PAMP to DAMP. Clin Immunol 144:32-40....
多项选择题 PRR识别的配体包括 A、PAMP B、CAMP C、DAMP D、GAMP 点击查看答案 你可能感兴趣的试题 单项选择题 在地壳深度范围内,一般随着埋深的增加,声波速度( );地层压力变大,声波速度( )()。 A、变小、变大 B、变大、变大 C、变大、变小 ...
Pisetsky DS (2012) The origin and properties of extracellular DNA: from PAMP to DAMP. Clin Immunol 144:32–40 CASPubMedPubMed CentralGoogle Scholar Quintana-Rodriguez E, Duran-Flores D, Heil M, Camacho-Coronel X (2018) Damage-associated molecular patterns (DAMPs) as future plant vaccines th...
Heat shock proteins (HSPs) are generally regarded as intracellular proteins acting as molecular chaperones; however, HSP72 can also be released from cells, and the implications of this release are not fully understood. Methods Human bronchial epithelial cells (16HBE14o-) were infected with RSV ...
它通过模式识别受体(pattern recognition receptor, PRR)识别具有病原体相关分子模式(pathogen associated molecular pattern, PAMP)或损伤相关分子模式(damage associated molecular pattern, DAMP)的生物大分子。PAMP包括病原体入侵所带来的一系列生物大分子,如细菌表面的脂多糖(lipopolysaccharide, LPS)、鞭毛、病毒入侵带来...
固有免疫细胞通常富集于黏膜表面、皮下和腹腔,是感染或危险发生的早期和初始部位,通过有限的PRR识别病原共有的PAMP或DAMP,启动快速而广泛的免疫应答,有效限制感染的程度和阻止病原体扩散。固有免疫应答不仅是机体抵御微生物侵袭的第一道防线,同时也密切参与并影响适应性免疫应答的启动、进程和效应。