Zhi-Zi-Da-Huangdecoction (ZZDHD) has been used for treatment of alcoholic liver disease in China for thousands of years. In order to reveal the dynamic biotransformation of the decoctionin vivo, a high-throughout, sensitive and special method based on high performance liquid chromatography ...
Zhi-Zi-Da-Huang decoction (ZZDHD), a classic traditional Chinese medicine (TCM) formula, has been used for centuries to treat alcoholic liver disease. Reliable therapeutics of ZZDHD has also been validated in clinical practice. In this study, molecular docking and network analysis were carried ...
In the present study, a comprehensive strategy based on UHPLC-FT-ICR-MS and serum pharmacochemistry was developed to reveal the bioactive constituents of Zhi-Zi-Da-Huang decoction (ZZDHD) against alcohol-induced hepatotoxicity in rats after oral administration. The chromatographic separation was achie...
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