Figure 14. SAR study of isoxazole-substituted oxazolo[5,4-d]pyrimidines as anticancer agents. 2.9.2. Caspase Cascade Activators Caspases represent a family of cysteine proteases for which a significant role in the signaling cascade leading to apoptosis has been demonstrated. These can be categori...
For the essential oil of the bark in the dry season, a total of 14 compounds were identified (Table 1). Terpenoids accounted for 30.05% of the compounds analysed (Table 2). Phytol (1, 9.76%) was the most abundant terpenoid. Other terpenoids found in relevant concentrations were linalool (...
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In an attempt to both increase the water solubility as well to probe the potential interactions with the hydrophobic pocket in the CS, we designed target compounds 4–14 by incorporating sp3 hybridized carbon atoms in the tricyclic scaffold of the lead compounds 1–3. (3) Variation of the ...
It was incubated for 35 min at 37 ˝C then the tubes were kept in an ice bath for 5 min Molecules 2016, 21, 266 14 of 17 and centrifuged again for 5 min. After centrifugation, the obtained supernatant was collected carefully and diluted with 900 µL of chilled PBS. All these ...
Keywords: 4H-benzochromene; 7H-benzochromenopyrimidine; 14H-benzochromenotriazolo- pyrimidine; antimicrobial activities; SAR 1. Introduction The development of antimicrobial agents is an area of great activity due to the emergence of multidrug resistance in common pathogens and the appearance of new ...
Molecules 2016, 21, 1144 14 of 23 The identity of [18F]1 was determined using the previously synthesized non-radioactive reference compound [37]. The reference compounds was coinjected with the radioligand for HPLC analysis and the identity confirmed by identical retention times using two ...