将AAV-DIO-eYFP注射到D1-Cre小鼠的VTA中,可以观察到D1神经元轴突在mPFC、NAc、LS、BLA和vHipp中的分布(图6A),这表明VTA D1神经元可能以这些脑区为靶点来调节焦虑样行为。为了确定参与调节焦虑的VTA D1神经元的可能靶点,将ChR2...
敲除Drd1基因exon 2,建立Drd1基因敲除小鼠模型。曾有基因修饰致死报导,详情点击基因信息中的MGI ID。 *使用本品系发表的文献需注明: Drd1-KO mice (Cat. NO. NM-KO-205028) were purchased from Shanghai Model Organisms Center, Inc.. 你也可能感兴趣...
D1-like receptor agonist treatment exacerbated lupus-like symptoms in pristane-induced lupus-like mice, while D1-like receptor antagonists alleviated the lupus-like phenotypes. Inhibition of D1-like receptor signals impeded B-cell differentiation, while activation of D1-like receptor signals could ...
将Kozak-Cre-pA-pGK-Neo插入到小鼠Foxd1基因起始密码子处。 *使用本品系发表的文献需注明: Foxd1-Cre-pGK-Neo mice (Cat. NO. NM-KI-241417) were purchased from Shanghai Model Organisms Center, Inc.. 相关品系 Foxd1-Flox 品系名:C57BL/6Smoc-Foxd1em1(flox)Smoc ...
Adora2aCre;Drd1-tdTomato and iMSN-Drd2HET;Drd1-tdTomato mice expressing ChR2 in iMSNs received saline or cocaine (15 mg/kg) daily for 5 days. Two to five days after the last injection GABA-A receptor-mediated synaptic responses were recorded under whole-cell voltage clamp in td...
By expressing channelrhodopsin selectively in D1‐ and D2‐ populations (using D1‐Cre and A2A‐Cre mice) in the NAc core, we show that mice will nose poke for optical self‐stimulation of both cell types, suggesting D2‐MSN activity is not inherently aversive....
Since mature, amidated gastrin (G-17) can induce cyclin D1, we determined whether G-17-mediated induction of cyclin D1 transcription involved Wnt signaling and CRE-binding protein (CREB) pathways. Our studies indicate that G-17 induces protein, mRNA expression and transcription of the G1- ...
Overexpression of p60v-src in MCF-7 breast cancer cells also activates cyclin D1 and involves activation of a cAMP-response element-binding protein (CREB)1 and activating transcription factor-2 (ATF-2) which interacts with a CRE at −66 in the cyclin D1 promoter (16). Cyclin D1 ...
mice.Drd1flox/floxhomozygous mice were crossed withαMHC-Cremice that were purchased from Jackson Laboratory (stock#009074, stock name: STOCK Tg (Myh6-cre)1Jmk/J) for the generation of CM-specificDrd1knockout mice. Deletion ofDrd1allele in the heart was examined by detection of floxed ...
To confirm this result, we employed Rosa-yellow fluorescent protein (YFP) reporter mouse and found that the emergence of DCX and YFP dual-positive cells after lentiviral expression of ND1-P2A-Cre under the control of the CD68 promoter was virtually abolished in the microglia-depleted brain (...