The DD-carboxypeptidase is inhibited non-competitively by penicillin G. The enzyme of the bacterial form is highly penicillin-sensitive (Ki= 4 × 10−9 M penicillin G). Inhibition is only partly reversible by treatment with penicillinase or by dialysis against buffer. In contrast, the DD-...
3 & Angel Manteca1 This work contributes to the understanding of cell wall modifications during sporulation and germination in Streptomyces by assessing the biological function and biochemical properties of SCO4439, a D-alanyl-D-alanine carboxypeptidase (DD-CPase) constitutively expressed during ...
D-alanyl-D-alanine carboxypeptidase IA (PBP5) is a penicillin-sensitive, membrane-bound enzyme required for trimming the carboxy-terminal D-alanyl residues from peptidoglycan pentapeptides. -lactam antibiotics act by binding covalently to PBPs resulting in their deactivation and ultimately leading to ...
DBVS was performed on two data sets (actives and decoys) of small molecules against eight structurally diverse protein targets: angiotensin converting enzyme (ACE), acetylcholinesterase (AChE), androgen receptor (AR), D-alanyl-D-alanine carboxypeptidase (DacA), dihydrofolate reductase (DHFR), estrogen...
GSH has a structure similar to the antibiotic precursors of Penicillium that work as inhibitors of the d-alanyl-d-alanine-carboxypeptidase (DacC) enzyme. DacC catalyzes glycopeptides (d-alanyl-alanine) to form peptidoglycan in cell walls. Our objective was to study the potential mechanism of GSH...
Chromophoric peptides, an agent containing them and their use for detection of DD-carboxypeptidases , Federal Republic of Germany, , , Circuito sintetico 4 620964-45-6 923-16-0 Condizioni di reazione + espansione Riferimento Solid-phase synthesis of fluorescent analogues of Park's nucleotide, l...
NAG N-acetylglucosamine N-acetylglucosamine NAM N-acetylmuramic acid N-acetylmuramic acid d-d-peptidases d-alanyl- d-alanine carboxypeptidases/transpeptidases d-alanyl- d-alanine carboxypeptidases/transpeptidases PBE penicillin-binding enzyme penicillin-binding enzyme DOI: 10.1016/0022-2836(89)90277-5...
dacC gene deletionEscherichia coliextracellular protein productiond〢lanylヾ゛lanine carboxypeptidase DacC is important for synthesis and stabilization of the peptidoglycan layer of Escherichia coli. In this work, dacC of E. coli BL21 (DE3) was successfully deleted, and the effects of this deletion ...
Association of a d-Alanyl-d-Alanine Carboxypeptidase Gene with the Formation of Aberrantly Shaped Cells during the Induction of Viable but Nonculturable Vibrio parahaemolyticus[J] . Wei-cheng Hung,Wann-Neng Jane,Hin-chung Wong.Applied and Environmental Microbiology . 2013 (23)...
xanthus, DD-carboxypeptidase, which functions in the regulation of the level of cross-linkage, was also induced by penicillin. When D-alanyl-D-alanine, the structure of which is similar to the -lactam structure of penicillin, was added to the developmental medium, 0.3 to 0.6 mMD-alanyl-D-...