during the course ofmacrophage activation. The buildup of D-2HG may be further explained by reduced expression of D-2HGDehydrogenase(D2HGDH), which converts D-2HG back into αKG, and showed inverse kinetics with HOT and D-2HG levels.We tested the immunomodulatory effects of D-2HG during...
l-Serine biosynthesis, a crucial metabolic process in most domains of life, is initiated by d-3-phosphoglycerate (d-3-PG) dehydrogenation, a thermodynamically unfavorable reaction catalyzed by d-3-PG dehydrogenase (SerA). d-2-Hydroxyglutarate (d-2-HG) is traditionally viewed as an abnormal meta...
Pseudomonas aeruginosa d-2-hydroxyglutarate dehydrogenase d-2-hydroxyglutarate d-malate reductive-half reaction Zn2+ metallo flavoprotein flavin inductively coupled plasma mass spectrometry induced-fit rapid-rearrangement mechanism Abbreviations D2HG d-2-hydroxyglutarate D2HGDH d-2-hydroxyglutarate dehydrogenase ...
d-2-Hydroxyglutarate (d-2-HG) is a metabolite involved in many physiological metabolic processes. When d-2-HG is aberrantly accumulated due to mutations in isocitrate dehydrogenase or d-2-HG dehydrogenase, it functions in a pro-oncogenic manner and is th
INTRODUCTION:Somatic mutations in the metabolic enzymes isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) confer gain-of-function activity in cancer cells, resulting in accumulation of the oncometabolite, R-2-hydroxyglutarate (2-HG). High... EM Stein,JK Altman,R Collins,... - 《Blood》 被引...
Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in glioma, which result in the accumulation of an “oncometabolite”, D-2-hydroxyglutarate (D-2-HG). Abnormally elevated D-2-HG levels result in a distinctive pattern in cancer biology, through competitively inhibiting α-ketog...