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[0050] 一种含酪丝缬肽(YSV)并基于L构型短肽自组装的悬浊液的制备,它是将抗癌短肽 YSV共价修饰到成胶因子NapGFFY的C末端,利用多肽Fmoc固相合成法合成目的多肽 NapGFFYGYSV,再经过反相高效液相色谱分离纯化得到纯品,在PBS中经加热冷却形成肉眼 可见的悬浊液。具体制备步骤如下: [0051] 一、多肽NapGFFYGYSV...
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实验目的: 本研究试图构建并评价一种新型多肽超分子水凝胶(Nap-GFFY)用于局部递送眼科药物双氯芬酸钠(DIC).双氯芬酸钠装载的Nap-GFFY多肽超分子水凝胶能有效增加药物角膜穿透能力,从而提高眼部生物利用度,进一步减少药物的不良反应. 实验方法: 本实验首先通过标准Fmoc固相多肽合成(SPPS)方法合成Nap-GFFY多肽序列(...
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