Cytotoxic T-cells are preferentially activated in the duodenal epithelium from patients with florid coeliac disease. J Pathol 2005;206:178-185.Buri C, Burri P, Bahler P, et al. Cytotoxic T cells are preferentially activated in the duodenal epithelium from patients with florid coeliac disease. J...
Cytotoxic T cells Cytotoxic T cells are CD8+ T cells that kill cells displaying specific and recognizable antigen to the T cell. Once activated by an antigen presenting cell, cytotoxic T cells undergo clonal expansion with help from IL-2 and release cytotoxins, such as perforin and granzyme. ...
killer T cell n. a killer cell that destroys target cells only when specifically activated by helper T cells. Comparenatural killer cell. Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved. ...
As a second model, interleukin-2 (IL-2)-activated human SMCY.A2 CTL27, which recognize an HLA-A2-restricted antigen encoded on the y chromosome, were confronted with male human melanoma cell lines BLM or MV3 (Supplementary Fig. 2e–i and Supplementary Movie 1). Compared to the MEC-1/...
细胞毒性t淋巴细胞活性检测方法进展 热度: 1 CytotoxicTLymphocytes (CTLs)andNKCells Afteractivation,naïveTcellsdifferentiate intoeffectorandmemoryTcells Afteractivation,Tcellsremaininlymphnodesfor5-6days EffectorTcells CellFunctionReleased Effector
Direct cell-to-cell contact is also critical for functionality. CD8+T cells can induce apoptosis by ligation of the receptor Fas and the Fas ligand (Fas L), which are expressed on lymphocytes and infected target cells. Activated CD8+T cells also produce several...
P14 TCR transgenic CD8+ T cells (LCMV gp33-specific) were activated by antigen in the presence of either IL-2 or IL-2 + IL-4 to generate effector cytotoxic T lymphocytes (CTLs). The therapeutic effectiveness of such IL-2- or IL-2 + IL-4-grown CTLs was tested in ...
T cells: A) are formed by the action of thymosin. B) are responsible for antibody-mediated immunity. C) originate in the spleen. D) produce antibodies when activated. E) all of the above. The activation of cytotoxic T cells can result ...
Taken together, these findings demonstrate that MM is associated with CD57(+)CD8(+) T-cell clones, raising the possibility that the expansion and accumulation of activated clonal CD8(+) T cells in MM may be the result of persistent stimulation by tumor-associated antigens, combined with a ...
SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8(+)T cell cytotoxic functionCD8 T-CELLS... X Liu,J Hao,Wei, PengZhao, XiaohongLan, QiuyanNi, LuChen, YongzhenBai, XueNi, LingDong, Chen - 《Science Advances》 被引量: 0发表: 2022年 Role of Ras...