www.nature.com/scientificreports OPEN Alterations of the cytoskeleton in human cells in space proved by life-cell imaging received: 27 September 2015 accepted: 23 December 2015 Published: 28 January 2016 Thomas J. Corydon1, Sascha Kopp2, Markus Wehland2, Markus Braun3,4, Andreas...
Recently, researches have revealed the key roles of the cytoskeleton in the occurrence and development of multiple diseases, suggesting that targeting the cytoskeleton is a viable approach for treating numerous refractory diseases. The cytoskeleton is a highly structured and complex network composed of ac...
Cytoskeleton and integrin-mediated adhesion signaling in human CD34+ hemopoietic progenitor cellshemopoietic progenitorscytoskeletonintegrinsadhesionsignalingSignificant progress has been made recently in the understanding of cell adhesion signaling. Many components of focal adhesion complexes have been identified in...
In this report, we analyze whether CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), can transduce an outside-in signal in human natural killer (NK) lymphocytes in vitro. We show that CD31, but not HLA class-I cross-linking triggers an outside-in transmembrane...
living forms on macroscopic scales, like most plants and fungi, constitutive cells are constantly remodeling their internalstructure for the entire organism to perform its metabolism, growth and reproduction [29]. In animalslike human beings, cell motility is at the basis of most – if not all ...
Buravkova LB,Romanov YA.The role of cytoskeleton in cell changes under condition of simulated microgravity. Acta Astronautica . 2001Burvakova LB,YA Romanov.The role of cytoskeleton in cell changes under condition of simulated microgravity. Acta Astronautica . 2001...
In Cell Biol. 11, 95-102. Ren, X.D. et al. 1999. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578-585. Benard, V. et al. 1999. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a...
We used human neuroblastoma cells and fluorescent dyes to detect changes in membrane potential, intracellular Ca 2+ concentration, cell detachment, and actin filaments. Fluorescence values were obtained with spectrofluorymetry, laser-scanning cytometry, and confocal microscopy; the last of these was ...
In human autoimmune diseases such as scleroderma, individuals produce antibodies to the pericentriolar material of the centrosome. Antiserum from such an individual has been used to follow the behavior of the centrosome during the cell cycle of mammalian cells. The scleroderma antiserum containing antibod...
We considered the possibility that the mutagen impact on the cytoskeleton could also impact cell shape. Thus, we obtained the perimeters and areas for 25 cells for each mutagen treatment level, and for the untreated cells, with results indicating a downward progression in the perimeter to area ra...