At the molecular level, the effect of mcu silencing appeared to be mediated by a significant decrease of Rho-family GTPases and Calpain activities, as a result of the global decrease of cytosolic and ER Ca2+ pools. Together, our results support a new role of the mitochondrial Ca2+ ...
The FAK/RhoA regulatory network may, thus, become a new target for the development of novel therapeutics for humans under spaceflight conditions with stressed physiological challenges, and for other human diseases. Keywords: SMG; apoptosis; focal adhesion complex; cytoskeleton; nuclear positioning; FAK...
A phylogenetic tree constructed from the syntenic orthologues of BHALIN [48] further emphasised the high level of sequence conservation (Figure 1A). Apart from a globular domain from aa 596-759, in silico analysis was unable to predict any protein functional domains (Figure 1B). The original ...
All the viruses have a capsid, which contains either double-stranded or single-stranded DNA or RNA. The shape of the capsid itself varies between viruses, and capsids are either enclosed within an envelope or naked (lacking an envelope). In order to reproduce, the virus must enter the host...
In conclusion, filamin-A is required for HIV entry into target cells, whereas in infected cells, it is strongly upregulated and promotes outbound viral release. However, since no changes were detected at the transcriptional level [99], the mechanism by which HIV increases filamin-A abundance,...
Protein expression level in the control sample was taken as 100%. Each result was expressed as a percentage of the value of the control sample. Each test was repeated three times. 2.5. Extracellular ATP Bioluminescence Assay Measurement of extracellular ATP in cell culture medium was performed ...