Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells.
Cytokine-cytokine receptor interaction Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and re...
Some DEGs involved in cytokine–cytokine receptor interaction pathways in water buffalo compared with yellow cattle, pre-infection.Jianmei YangZhiqiang FuYang HongHaiwei WuYamei JinChuangang ZhuHao LiKe LuYaojun ShiChunxiu Yuan
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基于KEGG通路富集分析的薏苡仁不同成分对Cytokine-cytokine receptor interaction靶基因作用,目的:探讨薏苡仁不同组分对脾虚湿阻证大鼠细胞因子-细胞因子受体相互作用的影响及关键靶点。方法:以薏苡仁不同组分作用于脾虚湿阻证大鼠,通过其肠全基因表达谱测定,对筛选的差异基
Cytokines act by binding to specific receptors in the plasma membrane of target cells. Knowledge of cytokine–receptor interaction (CRI) is very important for understanding the pathogenesis of various human diseases—notably autoimmune, inflammatory and infectious diseases—and identifying potential therapeuti...
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Cytokine and/or cytokine receptor engineering is being widely investigated to safely and effectively modulate cytokine activity for therapeutic benefit. IL-2 in particular has been extensively engineered, to create IL-2 variants that differentially exhibit activities on regulatory T cells to potentially ...
Once secreted, the cytokine binds to a specific protein molecule, called a receptor, on the surface of the target cell, an event that triggers a signaling cascade inside that cell. The signal ultimately reaches the nucleus, where the effects of the cytokine are manifested in changes in gene ...
coculture of macrophages and MSCs. To characterize this proteome, we determined the expression of molecules related to cellular immune response and tissue regeneration, as well as its possible toxicity and anti-inflammatory potency. The results show a specific molecular pattern of interaction between ...