Cytokine-cytokine receptor signaling(细胞因子-细胞因子受体信号传导)是一种细胞信号传导通路,涉及细胞因子与细胞表面受体的相互作用。细胞因子是一类小的、分泌型蛋白质,它们在细胞间通信中起着至关重要的作用。这些信号蛋白参与调节免疫反应、炎症、细胞生长、分化、细胞死亡、血管生成以及发育和修复过程,旨在恢复内环境...
Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells.
基于KEGG通路富集分析的薏苡仁不同成分对Cytokine-cytokine receptor interaction靶基因作用,目的:探讨薏苡仁不同组分对脾虚湿阻证大鼠细胞因子-细胞因子受体相互作用的影响及关键靶点。方法:以薏苡仁不同组分作用于脾虚湿阻证大鼠,通过其肠全基因表达谱测定,对筛选的差异基
This chapter describes the interaction of interleukin-6 (IL-6) with a soluble form of its cell surface receptor (sIL-6R), presents a procedure utilizing a competition approach that allows the determination of the equilibrium constant in solution thus avoiding any potential problems associated with ...
Cytokine-cytokine receptor interaction Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and re...
Accordingly, the present invention relates to preparing recombinant cells that express the IL-10 receptor and the newly identified IL-10 signal transduction protein, e.g., for use in screening libraries of compounds for IL-10 agonists and antagonists; to restoring IL-10 function to cells in ...
The focus of this chapter is to summarize signaling pathways activated by cytokine receptors and developmental regulation of the cytokine signaling pathway and the involvement of this pathway in human disease using the Erythropoietin Receptor (EPO-R) as a model. Cytokines regulate many steps of prolif...
The type I cytokine receptors also have sequence motifs in their cytoplasmic domains, called box 1 and box 2, that are responsible for receptor interaction with protein partners. The type II (non-hematopoietic) cytokine receptors are similar to type I cytokine receptors except they do not possess...
Cytokines (see Table 9.1) that bind the class of receptors, termed type I or hematopoietic cytokine receptor superfamily, include hormones, such as EPO, thrombopoietin (TPO), PRL, GH, and leptin; colony-stimulating factors (CSFs), such as granulocyte–colony-stimulating factors (G-CSFs), gran...
receptor - a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response anatomical structure, bodily structure, body structure, complex body part, structure - a particular complex anatomical part of a living...