However, it often induces life-threatening cytokine release syndrome (CRS) and neurotoxicity. Here, we show that in situ conjugation of polyethylene glycol (PEG) to the surface of CAR T cells ('PEGylation') cre
The infusion of chimaeric antigen receptor (CAR) T cells can trigger the release of life-threatening supraphysiological levels of pro-inflammatory cytokines. However, uncertainty regarding the timing and severity of such cytokine release syndrome (CRS) d
Background: CAR T-cell therapy is a promising treatment option for hematological malignancies. However, toxicities such as cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) associated with CAR T-cell therapies are challenging to manage. Tocilizumab, an ...
Cytokine release syndrome. Cytokine release syndrome(CRS) is a life-threatening complication of CAR T-cell therapy that presents similarly to sepsis and is characterized by high levels of cytokines. CRS may initially appear to be aflulike illness; however, severe cases can result in a runaway im...
英文:Cytokine release syndrome (CRS) 中文:细胞因子释放综合征 例句:A condition that may occur after treatment with some types of immunotherapy, such as monoclonal antibodies and CAR-T cells. Cytokine release syndrome is caused by a large, ra...
Cytokine Release Syndrome CTO1681: Orally bioavailable, steroid-sparing immunomodulator for multiple CRS-inducing cytokines Learn More CytoAgents Overview CytoAgents is developing CTO1681, a novel therapy for the treatment of Cytokine Release Syndrome (CRS), a dangerous and potentially life-threatening ove...
Cytokine release syndrome (CRS) is a potentially life-threatening condition that results from the pathologic over-activation of T cells, leading to hypersecretion of cytokines by T cells and other immune cell types. [1] Similar in presentation to a “cytokine storm”, which can be observed acro...
细胞因子释放综合征(Cytokine release syndrome,CRS)是由多种因素例如感染或者某些药物引起的全身性的炎症反应,起初被称细胞因子风暴,可引发体液中多种细胞因子如TNF-α、IL-1、IL-6、IL-12、IFN-α、IFN-β、IFN-γ、MCP-1和IL-8等迅速大量产生的现象,是引起急性呼吸窘迫综合征和多脏器衰竭的重要原因。
Monitoring and characterizing the response to CAR T therapy has been an ongoing challenge for researchers. Biomarkers associated with T cell activation and cytokine release syndrome (CRS) are of particular interest (2). Fast and accurate quantitation of such markers allows for the detailed analysis ...
Cytokine release syndrome (CRS) is a systemic inflammatory response characterized by the overexpression of inflammatory genes. Controlling CRS is essential for improving the therapeutic effects of chimeric antigen receptor (CAR) engineered T cells. However, current treatment options are limited given the ...