An analysis of STAT signaling pathways indicated that they play an important role in cytokine mediated PN1 gene expression. Prolonged activation of STAT1 in response to brief exposure to IFN-gamma for 5 min may mediate the long-term induction of PN1 gene expression at 7 hrs after the removal...
Intracellular retention of the NKG2D ligand MHC class I chain-related gene A in human melanomas confers immune privilege and prevents NK cell-mediated cytotoxicity. J Immunol. 2008;180(7):4606–14. Article CAS PubMed Google Scholar López-Soto A, et al. NKG2D signaling in cancer ...
In summary, germline mutations in genes regulating the granule-mediated cytotoxicity, innate immune system, and inflammasome activation were the leading causes of autoinflammatory diseases and autoimmune diseases triggering CRS, while CD8 T cells and innate cells are most likely the primary driver cells,...
We also highlight the application of these strategies to adjust the immunological imbalance in different immune-mediated disorders, including cancer, infection and autoimmune diseases. Finally, we look ahead to the hurdles that must be overcome before cytokine therapeutics can live up to their full ...
Among them, cytokine-induced Src homology 2 (SH2) protein (CIS) was found to inhibit the interleukin 3– and erythropietin-mediated STAT5 signaling pathway. However, involvement of SOCS proteins in other signaling pathways is still unknown. This study shows that the expression of CIS is ...
[83]. IL-6, produced bymonocytes, T lymphocytes, fibroblasts, andendothelial cells, stimulates collagen and TIMP-1 synthesis, and promotes a Th2-polarized immune response. Thebiological activitiesof IL-6 are mediated by means of the common Jak–Stat intracellularsignaling pathwayshared with other ...
RT Profiler PCR Array was used to study the expression of genes related to the toll-like receptor (TLR) pathway. We found that over-expression of CRNDE in astrocytes increased the expression of key factors in the toll-like receptor signaling pathway, especially toll-like receptor-3-mediated ...
Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Proper culmination of these diverse pathways forms the basis for an orderly generation of different ce... SJ Baker,SG Rane,EP Reddy - 《Oncogene》 被引量: 332发表...
et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207, 1625–1636 (2010). Article CAS PubMed PubMed Central Google Scholar Harrison, O. J. et al. Epithelial-derived IL-18 regulates Th17 cell differentiation and ...
et al. Blocking common gamma chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models. Sci. Transl. Med. 15, eabo0205 (2023). Article PubMed Google Scholar Liu, S. et al. A synthetic human antibody antagonizes IL-18Rbeta signaling through an allosteric mechanism. ...