Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism. J Pharm Pharmacol. 2009;61(1):47–54.Yang KH, Choi YH, Lee U, Lee JH, Lee MG. Effects of cytochrome P450 ...
(151 major, 130 minor), 263 as inhibitors (72 weak, 127 moderate, and 64 strong), and 23 as inducers of the CYP2C19enzyme[113]. About 541SNPshave been detected in theCYP2C19gene. The frequencies of the three majorCYP2C19geno-phenotypes in the control population areCYP2C19-*1/*1-EMs, ...
26,27 Since the initial description of selective chemical binders and enzymatic inhibitors such as CBZ,27,29 a translational evaluation of the targeting of CYP3A5 biological activity in cancer models has been awaited. Here, we established an HCI-based platform for advanced pharmaco-profiling of ...
Drugs as CYP3A probes, inducers, and inhibitors. Drug Metab. Rev. 39, 699–721 (2007). 10. Kirwan, C., MacPhee, I. & Philips, B. Using drug probes to monitor hepatic drug metabolism in critically ill patients: midazolam, a flawed but useful tool for clinical investigation of CYP3A ...
inhibitors and inducers of the major CYP drug metabolising enzymes. Although there are approximately 50 human CYP enzymes, only a small number of these are involved in drug metabolism. 2,3 The CYP isoforms of interest in drug metabolism are CYP3A4, CYP2D6, CYP1A2, CYP2C9 and CYP2C19. Th...
Supplementary Figs. 1–8 and Supplementary Table 2 (PDF 524 kb) Supplementary Table 1 CYP activity of substructures (XLS 870 kb) About this article Cite this article Veith, H., Southall, N., Huang, R.et al.Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical lib...
Assessment of the Effects of Abrocitinib on the Pharmacokinetics of Probe Substrates of Cytochrome P450 1A2, 2B6 and 2C19 Enzymes and Hormonal Oral Contraceptives in Healthy Individuals Article Open access 30 March 2024 Effects of strong and moderate CYP3A4 inducers on the pharmacokinetics of ...
Yang KH, Choi YH, Lee U, Lee JH, Lee MG. Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism. J Pharm Pharmacol. 2009; 61:47-54. [PubMed: 19126296]...
Yang SH, Lee MG (2008) Effects of CYP inducers and inhibitors on the ondansetron pharmacokinetics in rats: involvement of CYP2D subfamily and 3A1/2 for the ondansetron metabolism. J Pharm Pharmacol 60:853–861YANG SH,LEE MG.Effects of cytochrome P450(CYP)inducers and inhibitors on ondansetron...
YANG SH,LEE MG.Effects of cytochrome P450(CYP)inducers and inhibitors on ondansetron pharmacokinetics in rats:involvement of hepatic CYP2D subfamily and 3A1/2 in ondansetron metabolism [J].J Pharm Pharmacol,2008,60(7):853S.H. Yang, M.G. Lee, Effects of cytochrome P450 (CYP) inducers and...