Cytochrome P450 (P450 or CYP) enzymes are the major catalysts of oxidation of all drugs. Of the 57 human P450, 2/3 have been demonstrated to be capable of oxidizing or reducing some drugs but P450s 1A2, 2C9, 2C19, 2D6, and 3A4 are involved in most drug oxidations. Some other ...
【产品介绍】Cytochrome P450 3A4 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other ...
Drug metabolism as catalyzed by human cytochrome P450 systems. In A. Sigel, H. Sigel, and R. K. O. Sigel (eds.), The Ubiquitous Roles of Cytochrome P450 Proteins , Vol. 3, Wiley, Chichester, 2007, pp. 561–589.Astrid S, Helmut S, Roland S (2007) Drug metabolism as catalyzed by...
The information on specific cytochrome P450 enzymes involved in the metabolism of this drugs may help reveal potential drug interactions and interindividual variations in drug metabolism. Surprisingly, there are only few studies about the metabolism of TKIs in general [17], [18], [19], [20], [...
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogr... M Kazui,Y Nishiya,T Ishizuka,... - 《Drug Metabolism & Disposition the Biological Fate of Chemicals》 被引量: 1292发表: 2010年 ...
To predict how humans will metabolise xenobiotics, including drugs, human liver extracts and recombinant P450s have been used. New humanised mouse models are being developed which will be of great value in the study of drug metabolism, pharmacokinetics and pharmacodynamics in vivo, and in carrying...
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...
J.L. Rehmel, J.A. Eckstein, N.A. Farid, et al. Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450 Drug Metab Dispos, 34 (2006), pp. 600-607 View PDFView articleCrossrefGoogle Scholar ...
Drug Metabolism: Cytochrome P450 Reference Module in Biomedical Sciences 2021 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic or personal use only. Looking for a customized option? Contact sales for special pricing for your organizationCont...
Drug metabolism by cytochromes P450 in the liver and small bowel. Most drugs used clinically are metabolized by cytochromes P450. These enzymes have been best characterized in the liver, where it appears the major drug-me... PB Watkins - 《Gastroenterology Clinics of North America》 被引量: 37...