Cytidine diphosphate diacylglycerol per se is rarely noticed in analyses of lipid compositions of tissues, as it is present is such small amounts, perhaps only 0.05% or so of the total phospholipids. Indeed, the composition of the fatty acids or molecular species in this lipid in nature (as ...
Cytidine diphosphate diacylglycerol (CDP-DAG), an important intermediate for glycerolipid biosynthesis, is synthesized under the catalytic activity of CDP-DAG synthase (CDS) to produce anionic phosphoglycerolipids such as phosphatidylglycerol (PG) and cardiolipin (CL). Previous studies showed that ...
Here, the PA encounters cytidine triphosphate (CTP) formed by various nucleotide kinases from cytidine (or uridine) and, catalyzed by cytidine diphosphate-diacylglycerol (CDP-DG) synthase (CDS), PA and CTP react to yield CDP-DG. PI synthase (PIS) then catalyzes CDP-DG reaction with myo-...
Here, the PA encounters cytidine triphosphate (CTP) formed by various nucleotide kinases from cytidine (or uridine) and, catalyzed by cytidine diphosphate-diacylglycerol (CDP-DG) synthase (CDS), PA and CTP react to yield CDP-DG. PI synthase (PIS) then catalyzes CDP-DG reaction with ...
With this pipeline we uncovered a frequent cancer-specific SLI between the paralogs cytidine diphosphate diacylglycerol synthase 1 (CDS1) and CDS2 (p<0.001 in all three analyses). Essentiality of CDS2 is observed in one third of cultured cancers (DepMap). Using CRISPR-Cas9 we confirm the CD...
Cytidinediphosphate‐diacylglycerol synthase 5 is required for phospholipid homeostasis and is negatively involved in hyperosmotic stress tolerancedoi:10.1111/tpj.13916Hong, YueYuan, ShuSun, LinxiaoWang, XueminHong, YueyunPlant Journal
P.S. Uster, R.E. Pagano, Synthesis and properties of £uo- rescent analog of cytidine diphosphate-diacylglycerol and phosphatidylinositol, in: L. Freyz, H. Dreyfus, R. Massar- elli, S. Gatt (Eds.), Enzymes of Lipid Metabolism, vol. 2, Plenum, New York, 1986, pp. 493^500....
Both use PRPP as the source of ribose 1-phosphate. 6. UMP is converted to UTP by uridylate kinase and nucleoside diphosphate kinase. UMP+ATP⇌uridylate kinaseUDP+ADP UDP+ATP⇌nucleoside diphosphate kinaseUDP+ADP Formation of Other Pyrimidine Nucleotides...
In addition, in cultured neural cells, growth in inositol-free, chemically defined medium is required to maximize the Li + -dependent CDP-diacylglycerol response. A major advantage of this method may be its ability to provide insight Into the regulation of phosphoinositide turnover since this ...
Cytidine diphosphate-diacylglycerol (CDP-DG) synthase activity (EC 2.7.7.41) of a microsomal membrane preparation from suspension cultured Catharanthus roseus cells was characterized. The enzyme showed a pH optimum of 7.3 and apparent Km values for cytidine triphosphate (CTP) and phosphatidic acid (PA...