Activation induced cytidine deaminase (AID) is an enzyme essential for the generation of antibody diversity in B cells and is considered to be a general gene mutator. In addition, AID expression was also implicated in the pathogenesis of human B cell malignancies and associated with poor prognosis...
Molecular mechanisms of antibody somatic hypermutation. Hypermutation is triggered by activation-induced deaminase (AID), an enzyme which catalyzes targeted deamination of deoxycytidine residues in DNA. The pathways... JMD Noia,MS Neuberger - 《Annual Review of Biochemistry》 被引量: 1395发表: 2007年...
ObjectiveTo determine whether functional suppression of the catalytic domain of activation-induced cytidine deaminase (AID) can suppress the hyperreactive germinal center (GC) responses in BXD2 mice.MethodsWe generated transgenic BXD2 mice expressing a dominant-negative (DN) form of Aicda at the somat...
An antifungal agent, flucytosine (5-fluorocytosine), acts through conversion to 5-fluorouracil by cytosine deaminase in the fungal cells. Idoxuridine (iododeoxyuridine), another halogenated pyrimidine derivative, is used in viral infections. It is a competitive inhibitor (via phosphorylated derivatives)...
2′-Deoxycoformycin (pentostatin; DCF) is an adenosine analog that is a highly effective inhibitor of the purine biosynthetic enzyme adenosine deaminase (ADA). It is transported across cell membranes by facilitated nucleoside diffusion, where it binds tightly to ADA. Inhibition of ADA results in...
(iii) an activation-induced cytidine deaminase (AID)-related signature (signature 9). During B-cell development, AID induces deamination of cytosine to uracil. Resolution of these lesions by the error-prone DNA polymerase η (eta) results in A to C mutations at WA (W=A or T) motifs; ...
Prokaryotic expression of cytosine deaminase and the preparation of polyclonal antibody; 胞嘧啶脱氨酶的原核表达和多克隆抗体的制备 3. Study on killing efficacy of yeast cytosine deaminase /5 - fluorocytosine gene therapy system on K562B cell line; 酵母菌胞嘧啶脱氨酶/5-氟胞嘧啶基因治疗系统对K56...
Bloch A., et al., “The Role of the 5′-Hydroxyl Group of Adenosine in Determining Substrate Specificity for Adenosine Deaminase,” J. Med. Chem., 10(5):908-12 (Sep. 1967). Bryant M.L., et al., “Antiviral L-Nucleosides Specific for Hepatitis B Virus Infection,” Antimicrobial Age...
Background/Aim: Activation-induced cytidine deaminase (AID) is a DNA modifying enzyme which has an essential function in promoting antibody diversification. Its overexpression is strongly associated with B-cell derived malignancies including Burkitt lymphoma, where AID is required for the characteristic c...
The present invention provides a method for engineering B lymphocytes by utilizing the activation-induced cytidine deaminase of B lymphocytes. This avoids the use of engineered nucleases such as Cas nuclease. Engineered B cells are useful for customized antibody production and B cell therapy. Therefore...