Disclosed are peptides comprising a molecular scaffold portion and a loop portion that binds to integrin α v β 6 . This integrin is expressed on pancreatic tumors, making the peptides useful as imaging agents, among other uses. The peptides showed single-digit nanomolar dissociation constants ...
Cystine-knot peptides: emerging tools for cancer imaging and therapy. Expert Rev Proteomics 2014;11:561-572.Ackerman SE, Currier NV, Bergen JM, Cochran JR. Cystine-knot peptides: emerging tools for cancer imaging and therapy. Expert Rev Proteom. 2014;11:561-72....
Cystine-knot peptides are attractive templates in drug discovery due to a number of features they possess including their 3D conformation, physicochemical stability and synthetic tractability. Yet, their cellular uptake mechanisms remain largely unexplored. Recently, we demonstrated that the cystine-knot ...
However, examples of rotaxane substructure have been found in naturally occurring peptides, including : cystine knot peptides, cyclotides or lasso-peptides such as microcin J25.It's difficult to see cystine knot in a sentence. 用 cystine knot 造句挺难的 The growth factor cys...
A truncated form of the Agouti-related protein (AgRP), a member of the cystine-knot family, has shown promise as a scaffold for engineering novel peptides with new molecular recognition properties. In this study, we replaced a constrained six amino acid loop in AgRP with a nine amino acid ...
Advances in precision molecular imaging promise to transform our ability to detect, diagnose and treat disease. Here, we describe the engineering and validation of a new cystine knot peptide (knottin) that selectively recognizes human integrin αvβ6 wit
The loops have naturally occurring combinatorial diversity, which has led to cystine knot peptides being used as templates for drug design. The loop that cyclises the CCK motif (loop 6) is dashed. Aside from its topological allure, interest in the cystine knot motif derives mainly from its ...
and variety of bioactivities.Here we summarized the main structural features of both inhibitor cystine knot(ICK)peptide and cyclic cystine knot(CCK)peptide,including primary sequence,topology,permutation,synthesis and folding characteristics,as well as its applications on drug design and molecular ...
专利内容由知识产权出版社提供 专利名称:Cystine knot peptides binding to alpha IIb beta 3 integrins and methods of use 发明人:Jennifer R. Cochran,Adam P. Silverman,Mihalis S. Kariolis 申请号:US12938216 申请日:20101102 公开号:US08778888B2 公开日:2014 0715 摘要:Disclosed are peptides having a ...
Cystine knot proteins can be divided into two superordinate groups. (i) The cystine knot peptides, also referred to – with other non-cystine knot proteins – as knottins, with linear and cyclic polypeptide chains. (ii) The cystine knot growth factor family, which is in the focus of this...