Multiple cystic lung disease (MCLD) is a rare condition consisting of multiple, usually round, parenchymal lucencies of low-attenuating area with wall thickness less than 2 mm. The most characteristic clinical feature is pneumothorax, and diffuse cysts may lead to respiratory failure. Lymphangio...
Cases were anonymized, randomized and interpreted by 7 diffuse lung disease specialists and 15 non-specialist radiologists and pulmonologists. Clinical information other than age and sex was not provided. Prior to interpretation, non-specialists viewed a short PDF training document explaining cystic lung...
what roles exercise, diet, and nutrition play; what complications can occur and how they can be managed; when and why a lung transplant should be considered; what psychological effect the disease has on the patient's family; and how the special needs and concerns of adult CF patients can be...
46 This disruption of electrolyte transport in epithelial cells in the sweat ducts, airway, pancreatic duct, intestine, biliary tree, and vas deferens can variously cause elevated sweat chloride concentrations, viscous mucus production, lung disease, intestinal obstruction, pancreatic insufficiency, biliary...
The rabbit as a model for studying lung disease and stem cell therapy. Biomed Res Int. 2013;2013:691830. Article PubMed PubMed Central CAS Google Scholar Johnson-Delaney CA, Orosz SE. Ferret respiratory system: clinical anatomy, physiology, and disease. Vet Clin North Am Exot Anim Pract....
Candidate and genome-wide approaches have identified biologically plausible gene modifiers of lung disease severity, neonatal intestinal obstruction and diabetes in cystic fibrosis. Annotation of variants in CFTR will increase the utility of genetic testing in newborn screening, carrier testing and diagnosti...
Get PDF (140K) Keywords: pulmonary function; cystic fibrosis; preschool children; infection; inflammation; lung structure Abstract In cystic fibrosis (CF) lung function testing is a means of monitoring progression of lung disease. The preschool years have often been referred to as the “silent yea...
Effects of 12-week administration of dornase alfa in patients with advanced cystic fibrosis lung disease. Pulmozyme Study Group Chest, 110 (4) (1996), pp. 889-895 View PDFView articleCrossrefView in ScopusGoogle Scholar [31] L. Saiman, N. Mayer-Hamblett, P. Campbell, B.C. Marshall Hete...
lung infection change. Our OTU network was used to visualize the interrelationships within the CF lung as disease progresses. The data set was queried for co-presence or absence patterns between particular microbes. For every statistically significant event (p < 0.01, correlation >|0.2|), an...
disease progresses, may also affect mucus properties and further alter mucociliary transport and bring about pulmonary inflammation. As CF lung disease progresses, the sticky mucus formed generates microaerobic or even anaerobic settings within the normally aerobic environment [87]. Such a lung ...