Conese M. Cystic fibrosis and the innate immune system:therapeutic implications[J].Endocr Metab Immune Disord Drug Targets,2011.8-22.Conese M. Cystic fibrosis and the innate immune system: thera- peutic implications. Endocr Metab Immune Disord Drug Targets 2011; 11: 8-22....
The diagnosis of cystic fibrosis is based on typical pulmonary manifestations, GI tract manifestations, a family history, and positive sweat chloride test results (see Workup). Newborn screening for cystic fibrosis is universally offered in the United States. As a result of the complex and multi...
Columnist Lara Govendo is still balancing her immune system’s needs with those of her new lungs since her double-lung transplant years ago. Read the column Your CF community Visit theCystic Fibrosis News Todayforums to connect with others in the CF community. ...
Cystic fibrosis (CF), a clinically heterogeneous disease, is the first genetic disease for which adult population screening has been initiated in the United States. Since the discovery of the CFTR gene in 1989, much has been learned about the pathophysiology and molecular genetics of this disorder...
A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. BACKGROUND: Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-term trials, improves lung function in people with cystic fibro... E Mrrobinson - 《N Engl J Med》 被引量: ...
Yvonne C.W. Yau1,5, Valerie J. Waters1,6, D. Elizabeth Tullis7, David S. Guttman3,4,* & David M. Hwang1,2,8,* Chronic airway infections caused by Pseudomonas aeruginosa contribute to the progression of pulmonary disease in individuals with cystic fibrosis (CF). In...
Your lungs are well defended by the immune system(Image: Guy Viner/SPL) And… breathe.Twenty six years after the gene responsible for cystic fibrosis was identified, researchers have shown that people with the lung-damaging condition can benefit from gene therapy. ...
Mutations in CFTR, which form the basis for the clinical manifestations of cystic fibrosis, affect the epithelial innate immune function in the lung, resulting in exaggerated and ineffective airway inflammation that fails to eradicate pulmonary pathogens. Compounding the effects of excessive neutrophil ...
The ongoing Vitamin D for enhancing the Immune System in Cystic fibrosis (DISC) study, a multi-center, double-blind, randomized, placebo-controlled trial, will test the hypothesis of whether high dose vitamin D given as a single oral bolus of 250,000 IU to adults with CF during a ...
Neuropeptides in asthma, COPD and cystic fibrosis Asthma and COPD are common, chronic, and heterogeneous pulmonary diseases that have a significant impact on quality of life [45]. Asthma is primarily viewed as an inflammatory disorder of the airways and often is diagnosed at young age [37]. It...