Cystic fibrosis is a genetic disease affecting the exocrine glands, which are the organs responsible for making fluids in the body that is potentially fatal but treatable, especially when diagnosed early. Learn about the disease process of cystic fibrosis, including the mutated gene that causes it,...
Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells. Stem Cell Reports, 2015,4(4):569–577 PubMed PubMed Central Google Scholar Morgan RA, Gray D, Lomova A, et al. Hematopoietic Stem Cell Gene Therapy: Progress and Lessons Learned. ...
Ji HL, Chalfant ML, Jovov B, Lockhart JP, Parker SB, Fuller CM, Stanton BA, Benos DJ (2000) The cytosolic termini of the beta- and gamma-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channel. J Biol ...
Mouse as a Model of Growth Retardation in Cystic Fibrosis LEWIS A. ROSENBERG, MARK D. SCHLUCHTER, ALBERT F. PARLOW, AND MITCHELL L. DRUMM Departments of Genetics [L.A.R., M.L.D.], and Pediatrics [M.D.S., M.L.D.], Case Western Reserve University, Cleveland, OH 44106; National...
Table 1. Exercise training programmes in young people with cystic fibrosis: randomised controlled trials. StudyExercise training programmePulmonary functionAerobic fitnessMuscular strengthAnaerobic fitness Group (n)FrequencyIntensityDurationFEV1 (% predicted)FVC (% predicted) V˙O2peakLeg strengthPeak power (...
Pseudomonas aeruginosa is an environmentally ubiquitous Gram-negative bacterium and important opportunistic human pathogen, causing severe chronic respiratory infections in patients with underlying conditions such as cystic fibrosis (CF) or bronchiectasi
The airways of patients with cystic fibrosis (CF) are highly complex, subject to various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa is recognized as one of the most important pulmonary pathogens and the predominant
Pseudomonas aeruginosa (PA), one of the ESKAPE pathogens, is an opportunistic Gram-negative bacterium responsible for nosocomial infections in humans but also for infections in patients affected by AIDS, cancer, or cystic fibrosis (CF). Treatment of PA infections in CF patients is a global health...
This research was funded by the Cystic Fibrosis Trust UK under its programme grant for Strategic Research Centres (grant reference No RP-PG-0108-10011). The funder had no role in the conduct of the study, the writing of the manuscript, or the decision to submit it for publication. ...
GCAT genesT A C G GCAT Review Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward Ashley L. Cooney , Paul B. McCray, Jr. and Patrick L. Sinn * Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; ashley-peterson@uiowa.edu (A.L....