3. Describe the anatomy of the extrahepatic biliary system. Each liver lobe is drained by its own hepatic duct. The cystic duct supplies and empties the gallbladder. The cystic duct and the hepatic ducts converge to form the common bile duct (CBD). The CBD is located in the lesser omentum...
In subject area: Medicine and Dentistry CF is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and characterized by chronic airway infection and inflammation with cough, wheezing, and dyspnea due to thick and dehydrated secretions that overlap...
Digestive system complications include nutritional deficiencies including fat and fat soluble vitamins and diabetes (Nearly 20% of people with cystic fibrosis develop diabetes by age 30). Additionally, progressive hepatic dysfunction, gallstones, intestinal obstruction, intussusception, small intestine bacterial...
Shortly after identification of theCFTRgene, there was particular interest in and hope that insertion of a normal copy of the gene (that is, gene therapy) would restore CFTR function in persons with CF [5]. Gene therapy has long been promised as the pathway to a cure for CF and an assu...
Integrity of the biliary tree is imperative for liver function. Diseases that affect the bile duct integrity are common and often life-threatening. Although the adult liver is well-known for its regenerative capacity, the cellular events that drive repair of the bile duct system is not fully elu...
There, ingested food is broken down by digestive enzymes for ready absorption. Most digestive enzymes are secreted by the pancreas and arrive in the small intestine through the pancreatic duct. The pancreas effects a variety of exocrine and endocrine actions required for proper digestion, nutrition ...
function tests. Hepatomegaly may be attributable to either fatty infiltration of the liver or focal biliary fibrosis.[6][18]Common bile duct obstruction and cholecystitis may occur in 1% to 10% of patients presenting with abdominal pain and jaundice.[19]Severe CFLD occurs in 7% of patients ...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
23、rapyLimited successTransfer normal CFTR gene into epithelial cellsThe 1st phase 2b trial1: Cationic liposome systemSmall but significant benefit1 Cystic fibrosisgene therapy: the first trial.(Arch Dis Child. 2015 Sep;100(9):844)InfertilityMaleIntracytoplasmic sperm injectionFemalePulmonary function ...
MR-cholangiography gave the diagnosis of angiocholitis with cystic dilatation of the main bile duct (type Ia). Surgery was indicated. The procedure included a Y-loop hepato-jejunal anastomosis and cholecystectomy. The postoperative period was uneventful. Pathology reported a cystic formation with no ...