Cystatin C value in urine only increased in severe stages of CKD with serum creatinine values >1.4 mg/dL, while the urinary ferritin concentration increased in dogs with proteinuria and serum creatinine <1.4 mg/dL, being, therefore, a renal biomarker earlier than creatinemia....
Traditional analytes do not detect early renal disease; therefore there is a need to find new early markers of chronic kidney disease (CKD) in dogs to avoid the progression to irreversible renal damage. Our objective was to evaluate the presence of ferritin and cystatin C in urine of dogs wit...
Hypothesis/Objectives Urinary cystatin B (uCysB), a novel kidney injury biomarker, predicts progressive disease in International Renal Interest Society (IRIS) CKD Stage 1. Animals Seventy-two dogs, including 20 dogs from 4 university centers with IRIS CKD Stage 1, with IDEXX symmetric ...
No differences were observed in sCr and SDMA between the snake-envenomed group and the healthy control group. Spearman rank correlation analysis revealed a strong association of uClust with uCysB in the snake-envenomed dogs (r = 0.75 P < 0.001) but not in the healthy controls. The high ...
Changbaig HyunChoi B‐S, Moon H‐S, Suh S‐I, Hyun C. Evaluation of serum cystatin‐C and symmetric dimethylarginine concentrations in dogs with heart failure from chronic mitral valvular insufficiency. J Vet Med Sci. 2016, in press.
Results: Serum cystatin C concentrations (serum-[cystatin C]) were significantly lower in healthy dogs (1.29 (1.08-1.46) mg/ml) than in animals with renal disease (1.67 (1.46-1.87) mg/litre). There was a significant correlation between GFR values and the corresponding (serum-cystatin C; rs...
Urinary cystatin B concentrations at T1 were correlated with SSS (Spearman's 蟻=0.690, P < .001). The increased urinary cystatin B concentrations observed in dogs envenomated by V. berus in comparison to controls may indicate renal tubular injury in these patients....
In conclusion, high serum Cys-C concentrations in periodic health examinations in dogs <15kg predicted poorer prognosis for renal function.doi:10.1016/j.rvsc.2018.06.014Naoki Iwasa a bSatoshi Takashima bTatsuo Iwasa aKazuko Iwasa aTomomi Suzuki a...
Our hypothesis was that two novel tubular biomarkers, urinary clusterin (uClust) and cystatin B (uCysB), are elevated in dogs with AKI of different etiologies. In a prospective, longitudinal observational study, we collected serum and urine samples from 18 dogs with AKI of different severity and...