该类化合物对cyslt1受体有较强拮抗作用,可用于治疗cyslt1介导的哮喘、过敏性鼻炎等炎症性疾病,还可以用于预防和治疗神经退行性疾病(如多发性硬化症)。 背景技术: 1、1型半胱氨酰白三烯受体(the type 1cysteinyl leukotriene receptor,cyslt1r)属于视紫红质样a类g蛋白偶联受体(g protein-coupled receptors,gpcrs)...
CysLT1 receptor-induced human airway smooth muscle cells pro- liferation requires ROS generation, EGF receptor transacti- vation and ERK1/2 phosphorylation. Respir Res 2006; 7: 42.Ravasi S, Citro S, Viviani B, et al. CysLT1 receptor - induced human airway smooth muscle cells proliferation ...
企业类型:生产商 公司地址:上海上海 主营产品:活性小分子-抑制剂-激动剂-化合物库 展开更多产品简介 官网链接:https://www.medchemexpress.cn/Targets/Leukotriene Receptor/ltd-sub-4-sub-cyslt-sub-1-sub/antagonist.html 详细内容 详细内容 公司简介 LTD4/CysLT1 拮抗剂 MCE 站:LTD4/CysLT1 品牌:Med...
产品名称 Recombinant Cysteinyl Leukotriene Receptor 1 (CYSLTR1) 货号 KL11471RP 半胱氨酰白三烯受体1(CYSLTR1)重组蛋白 Recombinant Cysteinyl Leukotriene Receptor 1 (CYSLTR1) CYSLT1R; CYSLTR; HG55; HMTMF81; Cysteinyl leukotriene D4 receptor; G-protein coupled receptor HG55来源...
孤儿受体GPR17(the G protein-coupled receptor 17)属于视紫红质样A类G-蛋白偶联受体(G protein-coupled receptors,GPCRs)大家族,从系统发育树上看,GPR17处于P2Y12、P2Y13、P2Y14亚群和半胱氨酰白三烯受体(cysteinyl leukotrienes receptor,CysLT受体)的中间,GPR17具有典型的七次螺旋跨膜结构,人GPR17定位于染色体2q2...
英文名字 Cysteinyl Leukotriene Receptor 1 (CysLT1) Antibody 供应商 Imgenex 产品货号 IMG-71183 产品报价 ￥6008/0.05mg 产品说明书 点击查看 购买方式 产品新闻 背景资料 应用类型 IHC 免疫原 来源宿主 反应性 H 保存建议 其他 Imgenex 注意 该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文...
By immunocytochemistry, CysLT1 receptor expression was significantly increased in airway smooth muscle cells in allergen-treated mice compared with saline-treated controls and was reduced by montelukast, but not dexamethasone, administration. CONCLUSIONS: These data indicate that established airway smooth ...
Naidu, "�uanti�cation of montelukast, a selective cysteinyl leukotriene receptor (CysLT1) antagonist in human plasma by liquid chromatography-mass spectrometry: validation and its application to a human pharmacokinetic study," Biomedical Chromatography, vol. 23, no. 8, pp. 804-810, 2009....
Applicants herein incorporate by reference in its entirely the U.S. Provisional Application filed on Jun. 3, 2008, entitled ANTI-ADIPOCYTE FATTY ACID-BINDING PROTEIN(AP2),ANTIFLAPAND ANTI-CYSLT1RECEPTOR HERBAL COMPOSITIONS FOR PREVENTING AND CONTROLLINGASTHMAin the name of GOKARAJUet al. ...
Montelukast is a selective cysLT1 receptor antagonist, and is licensed for use as a treatment for asthma, as it reduces eosinophilic inflammation in the airways [8]. In addition to its primary mechanism of therapeutic activity, montelukast exhibits anti-inflammatory activity via a cyclic AMP-...