Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Accession Number DBCAT004028 Description Not Available Drugs DrugDrug Description Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Amiod...
Fernandez SA (2010) Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP450 3A4 substrates midazolam and nifedipine. Br J Clin Pharmacol 70:537-546.Zamuner S;Johnson BM;Pagliarusco S;.Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP...
探针底物(Probe substrate): 非那西丁(CYP1A2)、香豆素(CYP2A6)、安非他酮(CYP2B6)、紫杉醇(CYP2C8)、甲苯磺丁脲/双氯芬酸钠(CYP2C9)、奥美拉唑(CYP2C19)、美芬妥因(CYP2C19)、右美沙芬(CYP2D6)、氯唑沙宗(CYP2E1)、咪达坐仑 midazolam(CYP3A4)、睾酮(CYP3A4) 探针底物代谢产物(CYP450 probe subst...
睾酮(CYP3A4) 探针底物代谢产物/CYP450 probe substrates/metabolites: 对乙酰氨基酚(CYP1A2) 7-羟基香豆素(CYP2A6) 羟基安非他酮(CYP2B6) 6-羟基紫杉醇(CYP2C8) 4-羟基甲苯磺丁脲(CYP2C9) 右啡烷/去甲基右美沙芬(CYP2D6) 5-羟基奥美拉唑(CYP2C19) ...
saquinavir，indinavir CYP2D6CYP2E1 30%2% CYP3A4 50% 药物与CYP450酶的关系 酶的底物（Substrates）抑制剂（inhibitors）药酶活性减弱，使其他药物或本身代谢减慢,占代谢性相互作用的70% 诱导剂（inducers）药酶活性增强，使其他药物或本身代谢加速，占代谢性相互作用的23% P450酶的抑制 ...
咪达坐仑 midazolam(CYP3A4) 睾酮(CYP3A4) 探针底物代谢产物/CYP450 probe substrates/metabolites: 对乙酰氨基酚(CYP1A2) 7-羟基香斗素(CYP2A6) 羟基安非他酮(CYP2B6) 6-羟基紫杉醇(CYP2C8) 4-羟基甲苯磺丁脲(CYP2C9) 右啡烷/去甲基右美沙芬(CYP2D6) ...
酶的底物(substrates):具有特异型。我们重点讲解的是诱导剂。 CYP抑制和药物相互作用 多药联用治疗是一种常见的治疗方案,特别是对于那些有多病的病人中。理论上,如果两种药物被同时服用并竞争相同的CYP酶,药物的清除将受到阻碍,导致不可预料的药物积累和可能的毒副作用。CYP抑制检测成为体外预测可能存在的体内药药相...
P450亚族在药物代谢中的作用:CYP3A4,约占药物 50%CYP2D6,约占药物 30%CYP2C9,约占 10%CYP1A2,约占 4%CYP2A6 和 CYP2C19各占 2%Metabolic ContributionCYP 2D630%CYP 1A22%CYP 2C910%other3%CYP 3A455%CYP 3A4CYP 2D6CYP 2C9CYP 1A2otherhepatic only 酶的底物(Substrates) 抑制剂(inhibitors)药酶...
3 peptides for each isoform: 1A2, 2B6, 3A4, 3A5 1 mL 20% ACN, 0.1% TFA CYP450 Protein Assay - Human Induction Kit Storage IMPORTANT! When you receive the shipping container of CYP450 Protein Assay ‐ Human Induction Kit, immediately remove it ...
涉及药物代谢的CYP主要为CYP1、CYP2、CYP33个家族中7种重要的亚型：CYP1A2、CYP2A6、CYP2C9、CYP2C19、CPY2D6、CYP2E1和CYP3A4 与心血管药物代谢关系密切的有CYP1A2、CYP2C9、CYP2C19、CPY2D6、和CYP3A4 第七页，共41页。CYP450ActivityintheLiver RelativeImportanceof P450sinDrugMetabolism CYP2E1 CYP1A2 ...