While about half of drugs are metabolized by CYP3A4, in the pediatric propulsion there is a more limited set of drugs that are of primary concern. Experience in hospital treatment of pediatric patients lead to a more limited list of 35 important drugs based on occurrence and safety consideratio...
further Evidence for Interethnic Differences in the Oral Pharmacokinetics of Some Drugs Metabolized by Cyp3a4 in Mexican Healthy Volunteers: Evaluation of the Possible Influence of Cyp3a4*1b Polymorphism: poster #041José C. AguilarcarrascoHugo Antonio Hernándezpérez...
John's wort can activate CYP3A4, causing a decrease in the activity of many drugs. Quercetin, echinacea, and ginseng may have similar effects. Sign in as a member to see a list of medications that are metabolized by CYP3A4. Join today to unlock all member benefits including full access...
Synthetic cannabinoid designer drugs have emerged as drugs of abuse during the last decade, and acute intoxication cases are documented in the scientific literature. Synthetic cannabinoids are extensively metabolized, but our knowledge of the involved enzymes is limited. Here, we investigated the metaboli...
Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based Pharmacokinetic ModelCYP3A4hepatic ontogenyPBPK modelingpediatricsThe rapid growth in the use of pediatric physiologically based pharmacokinetic ...
Background: Several studies have demonstrated that renal impairment not only decreases renal clearance but also hepatic clearance of medications that are CYP3A4 substrates. We evaluated the influence of renal function on the pharmacokinetics of antiepileptic drugs metabolized by CYP3A4.Yamamoto, Yoshiaki...
Lu G, Abduljalil K, Jamei M, Johnson TN and Rostami-Hodjegan A (2012a) A Pregnancy Physiologically-Based Pharmacokinetic (p-PBPK) Model for Disposition of Drugs Metabolized by CYP1A2, CYP3A4 and CYP2D6. British Journal of Clinical Pharmacology 74:873-885....
Gaohua L, Abduljalil K, Jamei M, Johnson TN, Rostami-Hodjegan A. A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4. Br J Clin Pharmacol. 2012;74(5):873-85....
Toxicity Derived from Interaction between Natural Compounds and Cancer Therapeutic Drugs Metabolized by CYP3A4: Lessons Learned from Two Clinical Case ReportsST. John's (N.L.)BREASTPACLITAXELDRUG side effectsANTINEOPLASTIC agentsCYTOCHROME P-450 CYP3A...
While about half of drugs are metabolized by CYP3A4, in the pediatric propulsion there is a more limited set of drugs that are of primary concern. Experience in hospital treatment of pediatric patients lead to a more limited list of 35 important drugs based on occurrence and safety con- ...