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[9] du Souich P, Fradette C. 2011. The effect and clinical consequences of hypoxia on cytochrome P450, membrane carrier proteins activity and expression. Expert Opinion on Drug Metabolism and Toxicology 7: 1083–1100. [10] Montané, E., Arellano, A. L., Sanz, Y., Roca, J. and Farre...
[8] Wikipedia, CYP3A4. [9] du Souich P, Fradette C. 2011. The effect and clinical consequences of hypoxia on cytochrome P450, membrane carrier proteins activity and expression. Expert Opinion on Drug Metabolism and Toxicology 7: 1083–1100. [10] Mont...
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expressio...
M2,while 伪-naphthoflavone,sulfaphenazole,diethyldithiocarbamate,tranylcypromine and quinidine bad little or no inhibitory effecton the formation of M1 and M2.Conclusion:Vinflunine is rapidly metabolized inhuman liver microsomes,and CYP3A4 is the major human CYP450 involved in themetabolism of ...
CYP3A4 代谢药物的特点及其多态性的研究现状Research status of drug metabolism characteristics andpolymorphism of CYP3A4 作者：陈欣，李玉珍，方翼CHEN Xin，LI Yu-zhen，FANG Yi 北京大学人民医院药剂科Department of Pharmacy Peking University People’s Hospital （北京市西城区西直门南大街11 号邮编：100044）...
CYP3A5 Genotype has an Impact on the Metabolism of the HIV Protease Inhibitor Saquinavir Ritonavir, Indinavir, and saquinavir, all human immunodeficiency virus-1 protease Inhibitors with a potent antiviral effect during triple therapy, are exte... Josephson,F.,Allqvist,... - CLINICAL PHARMACOLOGY ...
CYP3A4代谢药物的特点及其多态性的研究现状ResearchstatusofdrugmetabolismcharacteristicsandpolymorphismofCYP3A4作者:**,李玉珍,方翼CHENXin,LIYu-zhen,FANGYi北京大学人民医院药剂科DepartmentofPharmacy,PekingUniversityPeople’sHospital(北京市西城区西直门南大街11号邮编:100044)摘要:目的:梳理分析CYP3A4的有关研究成果,更...
metabolism type recipients without CYP3A5(rs776746)*1 and CYP3A4(rs2242480)* 1G alleles(P<0.05) . D of tacrolimus was the highest in extensive metabolism type recipient and the lowest in poor metabolism type recipient. CONCLUSIONS:The detection of genetic polymorphism of CYP3A5(rs776746)and...
Aim: To study the metabolism of vinflunine and the effects of selective cytochrome P-450 (CYP450) inhibitors on the metabolism of vinflunine in human liver microsomes. Methods: Individual selective CYP450 inhibitors were used to investigate their effects on the metabolism of vinflunine and the princ...