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Drug-drug interactions mediated by cytochrome P450 enzymes: the role of inducers and inhibitors. Clin Ther. 2013;35:797–810. Google Scholar Edwards DJ, Bellevue FH 3rd, Woster PM. Identification of 6’,7’-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab ...
Conclusions Futibatinib is not expected to affect the exposure of concomitant medications metabolized via CYP3A, the most common drug metabolism pathway. Caution should be exercised when coadministering strong CYP3A inducers or inhibitors with futibatinib, as significant DDIs were observed with ...
25. Drug Development and Drug Interactions: Table of substrates, inhibitors and inducers. In: Development & approval process (drugs). U.S. Food and Drug Administration. 2014. http://www.fda.gov/drugs/ developmentapprovalprocess/developmentresources/ druginteractionslabeling/ucm093664.htm. Accessed 8...
The wide- spread involvement of CYP3A4 in drug metabolism is especially important to consider when treatment involves drugs that are substrates of CYP3A4, either inhibitors or inducers. In these situations, the impact of ontogeny on CYP3A4 in both pharmacokinetic study design and data ...