Llerena A, Dorado P, Pen˜as-Lledo´ EM, Ca´ceres MC, and De la Rubia A (2007) Low frequency of CYP2D6 poor metabolizers among schizophrenia patients. Pharmacogenomics J 7:408 - 410.Llerena, A., Dorado, P., Penas-Lledo, E. M., Cace- res, M. C., & De la Rubia, A....
Low frequency of CYP2D6 poor metabolizers among schizophrenia patients CYP2D6 has been suggested to be functionally similar to the dopamine transporter. The present study was aimed at analysing the frequency of CYP2D6 alleles ... A Llerena,P Dorado,EM Pe?As-Lledó,... - 《Pharmacogenomics Jour...
CYP2D6 poor metabolizers have no CYP2D6 activity (7% of whites and 1%-2% of other races). ... LJ De,MT Susce,RM Pan,... - 《Journal of Clinical Psychiatry》 被引量: 502发表: 2005年 The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naïve patients with first-episode ...
Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA: Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet. 1991, 48: 943-950. CAS PubMed PubMed Central Google Schol...
Based on the present and our previous data, the poor metabolizer frequency in Japanese was estimated to be 0.39%, which accounted for approximately 45% of the individuals phenotyped as poor metabolizers by in-vivo tests. 展开 关键词: CYP2D6*3 CYP2D6*4 CYP2D6*5 CYP2D6*18 genotype ...
Individuals with no functional CYP2D6 (i.e., poor metabolizers) had longer LSD half-lives and approximately 75% higher parent drug and main metabolite 2-oxo-3-hydroxy LSD area-under-the-curve blood plasma concentrations compared with carriers of functional CYP2D6. Non-functional CYP2D6 ...
Keywords: cyp2d6,poor metabolizer,metoclopramide,acute dystonia,metoclopramide-induced acute dystonic reactions,pharmacogenetics,pharmacogenomics Data availability: ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine Keywords: cyp2d6, poor metabolizer, metoclopramide, acute dystonia, metoclopramide-induced ...
Re: no evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluox- etine or nortriptyline. Hum Psychopharmacol 2005; 20:61-62.Gillman PK. Re: no evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with ...
Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. et al.Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-...
et al.Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure ... P Forget,B Le-Polain-De-Waroux,P Wallemacq,... - 《Journal of Pain & Symptom Management》 被引量: 0发表: 2008年 Diabetic neuropathy...