In conclusion, a homozygous CYP2C19*17 genotype is associated with lower serum concentration of escitalopram, which might imply increased risk of therapeutic failure. Clinical Pharmacology & Therapeutics (2008) doi: 10.1038/sj.clpt.6100291I Rudberg...
Geometric mean of the escitalopram serum concentration was 42% lower in patients homozygous for CYP2C19*17 ( P <0.01) and 5.7-fold higher in subjects homozygous for defective CYP2C19 alleles ( P <0.001). Of the heterozygous subgroups, only CYP2C19*1/def was significantly different from CYP2C19*...
摘要: 7 Malingre MM, Godschalk PC, Klein SK. A case report of voriconazole therapy failure in a homozygous ultrarapid CYP2C19*17/*17 patient comedicated with carbamazepine. Br J Clin Pharmacol 2012; 74: 205-6.DOI: 10.1111/bcp.12713 年份: 2015 ...
The frequency of the homozygous A/A variant of the CYP2C19*2 allele was significantly high and low in the Lur (P<0.001) and Caspian (P<0.001) ethnicities, respectively. However, the frequency of the homozygous A/A variant of the CYP2C19*3 allele was not detected in the Iranian cohort in...
In the 147 patients included in the PP analysis of the effect of CYP2C19 genotype, eradication rates were 88.9% (32/36) in poor metabolizers, 82.0% (50/61) in heterozygous extensive metabolizers, and 82.0% (41/50) in homozygous extensive metabolizers. Eradication rates did not differ ...
Methods Sixteen healthy volunteers participated in both study parts, five homozygous for CYP2C19*17 and 11 homozygous for CYP2C19*1 . Individual pharmacokinetic parameters were determined after single-dose omeprazole of 40mg and after 1 week on escitalopram 5mg b.i.d. Results Escitalopram area under ...
CYP2C79*17allele,exposure may be reduced by up to 50 percent compared with normal metabo-lizers.The authors of the comment also mention that they are not aware of published studies of homozygous CVP2C79*17/*17 patients; and they assume that these subjects would display further reduced ...
respectively, in the CYP2C19*17/*17 group (P = 0.20 and 0.17, respectively).In conclusion, we have shown that OC intake inhibits CYP2C19 in homozygous carriers of the CYP2C19 wild type but that the inhibition is not significant in heterozygous and homozygous carriers of the CYP2C19*17 allele....