21-23 We investigated whether a common genetic polymorphism (CYP1A2*1F) that results in a “slow” metabolizer phenotype modifies the association between intake of caffeinated coffee and risk of nonfatal MI. Our findings show that coffee consumption increases the risk of MI only among individuals...
The aim of this study was to obtain a clear understanding of the molecular mechanisms underlying inter-individual variation in baicalin inhibition on CYP1A2 through a phenotype–genotype analysis of well-characterized human livers. Phenotype measures included Michaelis constant...
Accordingly, the polymorphism of the enzyme results in poor, intermediate, extensive or ultrarapid metabolizers of CYP2D6 drugs. The CYP2C19 gene, located on chromosome 10, is also highly polymorphic exhibiting 47 currently known star alleles....