In transgenic mice engineered to mimic the smallest truncation found in cylindromatosis patients, CYLD interaction with CAP350 is lost disrupting CYLD centrosome localization, which results in cilia formation defects due to impairment of basal body migration and docking. These results point to an ...
Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4 Authors - Chenggang Zhang View Article human WB,IHC Chem Biol Interact miR-501 is upregulated in cervical cancer and promotes cell proliferation, migration and invasion by ...
ArticlePubMedPubMed CentralGoogle Scholar Shi X, Sun X, Liu M, Li D, Aneja R, Zhou J . CEP70 protein interacts with gamma-tubulin to localize at the centrosome and is critical for mitotic spindle assembly.J Biol Chem2011;286:33401–33408. ArticleCASPubMedPubMed CentralGoogle Scholar Butle...
The ciliary function of CYLD is partially attributed to its deconjugation of the polyubiquitin chain from centrosomal protein of 70 kDa (Cep70), a requirement for Cep70 to interact with γ-tubulin and localize at the centrosome. In addition, CYLD-mediated inhibition of histone deacetylase 6 (...
Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase. During metaphase, it remains localized to the centrosome but is also present along the spindle (PubMed:25134987). Database Links: Entrez Gene: 1540?Human ...
Subcellular Location: Cytoplasm Cytoplasm, perinuclear region Cytoplasm, cytoskeleton Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, cilium basal body Detected at the microtubule...
2019年11月25日,上海交通大学医学院上海市免疫学研究所苏冰教授、杨晓东副研究员研究团队在EMBO Journal发表了题为“PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome”的研究论文,报道了去泛素化酶复合物Spata2-CYLD在细胞中心体中调控NLRP3炎症小体活化...
Cell membrane Cytoplasm Cytoplasmic side Peripheral membrane protein centrosome cilium basal body cytoskeleton microtubule organizing center perinuclear region spindle 关键字:Anti-CYLD Polyclonal Antibody;抗体 公司简介 北京索莱宝科技有限公司是一家集研发、生产、销售、服务于一体的高科技生物企业。技术推广;技术转让...
(pAb); Primary antibody Isotype IgG Purification method Affinity purification Positive samples U-87MG, HL-60, HT-1080, Mouse kidney, Mouse brain Cellular location Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, centrosome, cilium basal body, cytoskeleton, microtubule organizing ...
Here, we show that CYLD localizes to the centrosome in cells and is enriched in purified centrosomes. To understand the functional interaction between CYLD and CAP350, we studied mice carrying deletion of part of the deubiquitinase domain and mimicking the human pathology. These homozygous mice ...