Facebook Twitter Google Share on Facebook cyclophosphamide Medical Acronyms Encyclopedia Wikipedia Related to cyclophosphamide:vincristine cy·clo·phos·pha·mide (sī′klə-fŏs′fə-mīd′) n. A cytotoxic, immunosuppressive, antineoplastic drug, C7H15Cl2N2O2P, used in the treatment of Hodgkin...
by alkylating its nucleophilic bases, leading toapoptosis. This, in turn, affects the immune system by suppressing the number and function of B and T cells, inhibiting both the cellular andhumoral immune response[80].Acroleinis another metabolite of cyclophosphamide, responsible forbladdertoxicity[81...
Cyclophosphamide side effects (more detail)WarningsYou should not use cyclophosphamide if you have a bladder obstruction or other urination problems.Before taking this medicineYou should not use cyclophosphamide if you are allergic to it, or if you have:...
CLL and cancer of the ovary and bladder. Because it is associated with a relative lack of non-blood based toxicities, it can be used in high dose regimens. It is administered intravenously or can be taken orally
Protracted cases have been treated with 1–10% formaldehyde irrigations, electrocautery to the telangiectatic areas of the bladder, diversion of urine flow, and cryosurgery.Other Genitourinary EffectsBladder fibrosis (sometimes extensive), with or without cystitis....
Cyclophosphamide is a commonly used chemotherapeutic drug to treat cancer with side effects that trigger bladder injury and hemorrhagic cystitis. Although previous studies have demonstrated that certain cell subsets and communications are activated to drive the repair and regeneration of bladder, it is ...
Confirmed human carcinogen producing leukemia, Hodgkin's dsease, gastrointestinal and bladder tumors. Experimental carcinogenic, neoplas tigenic, and teratogenic data. A human poison by ingestion and many other routes. Human systemic effects: hdney changes (hepatic dysfunction), leukopenia (reduced white...
Compared to oral therapy alone, intravesical therapy might provide the benefit of establishing a higher concentration directly into the bladder with a minimum risk of systemic side effects. Overall, there have been very limited reports regarding the use of oral PPS in HC (and no intravesical ...
This medicine is used for the treatment of breast cancer, brain cancer, lymphoma, leukemia, sarcoma, osteosarcoma, neuroblastoma, multiple myeloma, bladder cancer, ovarian cancer, testicular cancer, cervical cancer, endometrial cancer, prostate cancer, small and non-small cell lung cancer, Hodgkin's...
Urotoxicity (bladder ulceration, necrosis, fibrosis, contracture and secondary cancer) may require interruption of cyclophosphamide treatment or cystectomy. Urotoxicity can be fatal. Urotoxicity can occur with short-term or long-term use of cyclophosphamide. Before starting treatment, exclude or correct...