A concise and efficient synthesis of cyclooctane-1,2,3,4-tetraoles, new polyhydroxylated eight-membered carbocycles, is described starting from cis, cis-1,3-cyclooctadiene. Cyclooctene endoperoxide obtained by photooxygenation of cis, cis-1,3-cyclooctadiene was the key compound in the synthesis....
The cis and trans isomers of diol 4 (4a and 4b) have been identified by spectral and chemical means and we have investigated its optimal experimental conditions. Our ultimate aim is to achieve a potential energetic intermediate, containing difluoramino structural components, initiated by amination...
While the IC50 of 28 in A2780 cells was 0.72 nM, the resistant A2780cis cells exhibited an IC50 of 1.82 nM. Although complete resistance reversal was not achieved, the results highlight the promising potential to partially overcome resistance. We also assessed its selectivity by comparing the ...