12.1 Mechanism of Action Cyclobenzaprine relieves skeletal muscle spasm of local origin without interfering with muscle function. Cyclobenzaprine has not been shown to be effective in muscle spasm due to central nervous system disease. In animal models, cyclobenzaprine reduced or abolished skeletal muscle...
of-action targets for drugs and probesProc. Natl. Acad. Sci. USA109(28)11178-11183(2012) 5.Honda, M., Nishida, T., and Ono, H.Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT2 receptorsEuropean Journal of Pharmacology458(1...