环苯扎林在2.5 mg至10 mg的剂量范围内表现出线性药代动力学, 并经历肝肠循环。它与血浆蛋白高度结合。每天给药3次后,药物会积聚,在3至4天内达到稳态,血浆浓度约为单次给药后的四倍。 在健康受试者接受10 mg tid(n = 18)的稳态下,血浆峰值浓度为25.9 ng / mL(范围为12.8至46.1 ng / mL), 并且在8...
HCl 5 mg N=464Cyclobenzaprine HCl 10 mg N=249Placebo N=469 Drowsiness 29% 38% 10% Dry Mouth 21% 32% 7% Fatigue 6% 6% 3% Headache 5% 5% 8% Adverse reactions which were reported in 1% to 3% of the patients were: abdominal pain, acid regurgitation, constipation, diarrhea, dizziness, na...
Common Generic Name(s):cyclobenzaprine, cyclobenzaprine HCl, cyclobenzaprine hydrochloride Pronunciation:SYE-kloe-BEN-za-preen Drug Classes:muscle relaxant Availability:prescription only, generic available How is it used?capsule that is swallowed, tablet that is swallowed ...
CYCLOBENZAPRINE HCL 1.2 Synonyms 環ベンゼン紮林; 사이클로벤자프린; 1-Propanamina,3-(5H-dibenzo[a, d]ciclohepten-5-ilideno)-N, N-dimetil-; 1-Propanamine, 3- (5H-dibenzo < a, d > cyclohepten 5-ylidene) -N, N-diméthyl-; 1-Propanamin, 3- (5H-dibenzo Bulgaria ...
简介环苯扎林是一种拮抗 ADRA2、5-HT2A 受体和 H1 受体的小分子药物,已被批准用于治疗肌肉痉挛、纤维肌痛、应激障碍、腰痛、COVID-19 和 COVID 后综合征。它的作用机制降低了运动神经元和骨骼肌的兴奋性,同时减少了焦虑、疼痛和炎症。强生公司开发的这种药物于 1977 年首次获得批准,但它会引起嗜睡、口干和头晕...
Common Generic Name(s): cyclobenzaprine, cyclobenzaprine HCl, cyclobenzaprine hydrochloride Pronunciation: SYE-kloe-BEN-za-preen Drug Classes: muscle relaxant Availability: prescription only, generic available How is it used? capsule that is swallowed, tablet that is swallowed ...
Cyclobenzaprine hydrochloride, USP is supplied as a 5 mg, 7.5 mg and 10 mg tablet for oral administration. Each 5mg, 7.5mg and 10mg contains cyclobenzaprine hydrochloride and the following inactive ingredients: croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline ...
slightly soluble in chloroform and in methylene chloride and insoluble in hydrocarbons. If aqueous solutions are made alkaline, the free base separates. Cyclobenzaprine HCl is designated chemically as 3-(5H-dibenzo[a,d] cyclohepten-5-ylidene)-N, N-dimethyl-1-propanamine hydrochloride, and has th...