环苯扎林在2.5 mg至10 mg的剂量范围内表现出线性药代动力学, 并经历肝肠循环。它与血浆蛋白高度结合。每天给药3次后,药物会积聚,在3至4天内达到稳态,血浆浓度约为单次给药后的四倍。 在健康受试者接受10 mg tid(n = 18)的稳态下,血浆峰值浓度为25.9 ng / mL(范围为12.8至46.1 ng / mL), 并且在8...
Common Generic Name(s):cyclobenzaprine, cyclobenzaprine HCl, cyclobenzaprine hydrochloride Pronunciation:SYE-kloe-BEN-za-preen Drug Classes:muscle relaxant Availability:prescription only, generic available How is it used?capsule that is swallowed, tablet that is swallowed ...
Adult: 5 mg orally every 8 hours, may increase the dose to 7.5-10 mg orally every 8 hours as needed Under 15 years of age: Safety and efficacy not established Over 15 years of age: 5 mg orally every 8 hours, may increase the dose to 7.5 mg orally every 8 hours as needed ...
(a,d)cycloheptene-delta5,gamma-propylamine, N,N-dimethyl-; 5H-Dibenzo[a,d]cycloheptene-Δ5,γ-propylamine, N,N-dimethyl-; 9715 R.P; Amrix; CYCLOBENZAPRINE; CYCLOBENZAPRINE HCL; MK 130; N,N-Dimethyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine; Proheptatrien; Proheptatriene; Ro 4...
Cyclobenzaprine hydrochloride, USP is a white to off-white crystalline powder with the molecular formula C20H21N•HCl and a molecular weight of 311.9. It has a melting point of 217° C, and a pKaof 8.47 at 25° C. It is freely soluble in water, in alcohol and in methanol, sparingly...
10. Bianchi M. Evaluation of cyclobenzaprine for skeletal muscle spasm of local origin. In: Clinical Evaluation of Flexeril (Cyclobenzaprine HCl/MSD). Minneapolis, MN: Postgraduate Medicine Communications; 1978:25-29. 11. Brown BR Jr, Womble J. Cyclobenzaprine in intractable pain syndromes with mu...
In a 105-week carcinogenicity study, malignant astrocytoma was seen in 3 of 50 male rats at 10 mg/kg/day (approximately 3 times the MRHD on a mg/m2 basis). There were no tumor findings in female mice or rats. Mutagenesis Cyclobenzaprine HCl was not mutagenic or clastogenic in the ...
Cyclobenzaprine (Flexeril, others) - Uses, Side Effects, and More Medically Reviewed by Beth Johnston, PharmD, BCPS on Oct 06, 2024 | Written by M. Sruthi, MBBS Common Brand Name(s): Amrix, Fexmid, Flexeril Common Generic Name(s): cyclobenzaprine, cyclobenzaprine HCl, cyclobenzaprine hydroch...
5 mg studies (incidence of > 3% on cyclobenzaprine hydrochloride 5 mg): Cyclobenzaprine HCl 5 mg N=464Cyclobenzaprine HCl 10 mg N=249Placebo N=469 Drowsiness 29% 38% 10% Dry Mouth 21% 32% 7% Fatigue 6% 6% 3% Headache 5% 5% 8% ...
Cyclobenzaprine hydrochloride, USP is a white, crystalline tricyclic amine salt with the molecular formula C20H21N·HCl and a molecular weight of 311.9. It has a melting point of 217°C, and a pKa of 8.47 at 25°C. It is freely soluble in water and alcohol, sparingly soluble in isopropan...