Cyclobenzaprine and back pain: a meta-analysis. Background: Back pain is a common problem for which cyclobenzaprine hydrochloride is frequently prescribed. Objective: To perform a systematic review of cy... R Browning,JL Jackson,PG O'Malley - 《Archives of Internal Medicine》 被引量: 188发表:...
In summary, CER is the only extended-release formulation of cyclobenzaprine available. The Diffucaps technology makes once-daily dosing possible, which has been associated with an improved tolerability relative to CIR. The efficacy of CER and CIR has been shown to be similar in clinical studies; ...
Study comparisons included the plasma cyclobenzaprine AUC to 168 hours after dosing (AUC 0–168), AUC 0–∞, and C max. Plasma cyclobenzaprine T max, terminal elimination t 1/2, and adverse events (AEs) were also assessed. Results: Sixteen subjects (9 women, 7 men) were randomized to ...
Doses and dosing regimens can be determined by one of skill in the art according to the needs of a subject to be treated. The skilled worker may take into consideration factors such as the age or weight of the subject, the severity of the disease or condition being treated, and the ...
in normal healthy volunteers, the AUC at steady state (after 4 days of dosing) was 177 ng·hr/mL (range, 80-319 ng·hr/mL) and the Cmax was 25.9 ng/mL (range, 12.8-46.1 ng/mL). Additional pharmacokinetic properties of orally administered Cyclobenzaprine can be found, for example, in...
Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly). HOW SUPPLIED Cyclobenzaprine hydrochloride, USP 5 mg tablets are supplied as butterscotch yellow colored film-coated capsule shaped convex tablets,...
A 52-year-old woman with a history of leiomyoma uteri and tobacco-use disorder in remission presented with 2 months of progressive back pain. Her pain was located between her shoulder blades and was described as constant with intermittent sharp, stabbing sensation. It was nonradiating and aggravat...
Less frequent dosing should be considered for hepatically impaired or elderly patients (seePRECAUTIONS,Impaired Hepatic Function,and Use in the Elderly). HOW SUPPLIED Cyclobenzaprine hydrochloride tablets, USP are available in 7.5 mg dosage strengths. The dosage strengths are supplied as follows: ...