10. Overdosage 10.1 Manifestations Although rare, deaths may occur from overdosage with cyclobenzaprine hydrochloride extended-release capsules. Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended ...
DOSAGE AND ADMINISTRATION For most patients, the recommended dose of cyclobenzaprine hydrochloride is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of cyclobenzaprine hydrochloride for periods longer than two or three weeks...
主要研究目的: 考察在空腹/餐后条件下,在中国健康受试者中评价鲁南贝特制药有限公司研制的盐酸环苯扎林缓释胶囊(规格:30mg)与Teva Pharmaceuticals International GmbH持有的盐酸环苯扎林缓释胶囊(商品名:Amrix;规格:30mg)的人体生物等效性。 次要研究目的 观察在空腹/餐后条件下,盐酸环苯扎林缓释胶囊受试制剂和参比制...
Estimates of mean oral bioavailability of cyclobenzaprine range from 33% to 55%. Cyclobenzaprine exhibits linear pharmacokinetics over the dose range 2.5 mg to 10 mg, and is subject to enterohepatic circulation. It is highly bound to plasma proteins. Drug accumulates when dosed three times a day,...
DOSAGE AND ADMINISTRATION For most patients, the recommended dose of Cyclobenzaprine hydrochloride is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of Cyclobenzaprine hydrochloride for periods longer than two or three weeks...