Cyclins were originally discovered by the British biochemist and molecular physiologist Richard Timothy Hunt (1945-) in 1982 while studying the cell cycle of sea urchins. He was awarded the ___ Nobel Prize in Physiology or Medicine with Paul Nurse and Leland H. Hartwell for their discoveries...
Cyclins are known effectors of cellular proliferation. While originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. One of these viruses is HHV-8, a gamma herpesvirus implicated as a causative ...
share all the properties that originally defined cyclins: they are CDK activators that are periodically expressed and catabolized during different phases of the cell cycle [12]. They have also been named “cell cycle cyclins” [18], a designation that is better avoided as it excludes a “cell...
Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Recommended articles Lactobacillus plantarum AN1 cells increase caecal L. reuteri in an ICR mouse model of dextran sodium sulphate-induced inflammatory bowel disease International ...
All animals were studied according to the guidelines from Directive 2010/63/EU of the European Parliament.Hmox1−/−mice (back-crossed 10 generations into the C57BL/6 background) were originally generated by Dr S-F Yet (Pulmonary and Critical Care Division, Brigham and Women’s Hospital, ...
It was originally reported, based largely on in vitro cell culture systems, that E2Fs1–3 act as activators of transcription and can induce proapoptotic genes when overexpressed (for review, see DeGregori and Johnson, 2006, Iaquinta and Lees, 2007). However, genetic experiments from the Leone...
This reorientation of the investigation in the light of ongoing research advances can be accommodated within the framework of the originally requested funds and resources.Langan, T. A.Colorado Univ. at Denver.
Entry into mitosis is determined by the activation of an M-phase-specific protein kinase, originally known as M-phase-promoting factor (MPF)—the universal, highly conserved activity capable of inducing M phase when introduced into Xenopus oocytes or activated egg......
Cyclins are known effectors of cellular proliferation. While originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. One of these viruses is HHV-8, a gamma herpesvirus implicated as a causative ...