首先合成了WX-02308的衍生物,在色氨酸核心的不同位置连接PEG3-甲酯连接基,通过GEL-ABPP实验,发现WX-02-588及其对映体WX-02-589在C3位的PEG3-甲酯修饰具有更好的立体选择性;随后将荧光染料偶联至这两种化合物,生成YZ-01-A和YZ-01-B;利用GEL-ABPP...
Zhang Y, Liu Z, Hirschi M, et al. An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes[J]. Nature Chemical Biology, 2024: 1-12.
Zhang Y, Liu Z, Hirschi M, et al. An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes[J]. Nature Chemical Biology, 2024: 1-12.
白质。含一个与CDKs相互作用的细胞周期素盒 (cyclinbox)。CyclinE合成出现在G1中期,S期含量最高而后逐渐降解消失,在G2和M期不表达, 2 CyclinE2CDK2的分子活性调节机制 211转录水平的调节 CyclinE2CDK2的分子活性在转录水平受多种因子调节。CyclinE启动子上含多种细胞因子结合位点,细胞因子通过与之相互作用来调控Cycli...
Doxycycline is a well-tolerated drug that has a half-life duration of 18–22 h, and the ability to penetrate the blood-brain barrier (Chen et al., 2016a,b;Scatena et al., 2018). Importantly, no significant differences have been identified in the serum half-life of doxycycline in indi...
Tadesse S.,et al., 2020Drug Discovery Today25(2):406-413. ● Datasheets/Protocols 82228 ●General Protocols ●FAQs ●Contact Technical Service ● Related Content Advances and Challenges in Targeting Kinases in Cancer Therapeutics Video Luminescence Kinase Assays Illuminate the Path to Inhibitor Discov...
et al (Xinhui People's Hospital ,Guangdong J iangmen 529100 ,China ) Abstract :Objecfi ve :To stud), the relationship between the expression of CyclinE and prognosis in breast cancer tissues.Methods :The expression of CyclinE ,ER ,PR ,C — erbB 一2 ( HER 一2/neu) was ...
前言 在哺乳动物中,细胞分化周期由Cdks直接控制,Cdks由各种调控蛋白控制,包括Cyclins激酶和磷酸及cdk抑制物.p27~(Kip1)是一个cdk抑制物,通过结合在CyclinE/cdk2复合体... 刘焰 - 《中国医科大学》 被引量: 0发表: 2002年 Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors ...
CDK3/CyclinE1 英文名称: CDK3/CyclinE1 总访问: 544 国产/进口: 进口 半年访问: 2 产地/品牌: bps 产品类别: 生化试剂 规格: 40103 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 [发表评论] [本类其他产品] [本类其他供应商] [收藏] 分享:微信新浪微博销售商: ...
The cyclin E /Cdk2 substrate p220 NPAT is required for Sphase entry, histone gene expression, and Cajal body maintenance in human somatic cells. Mol Cell Biol, 2003,23:8586～8600.16 Ma Tianlin, van Tine B A, Harper J W, et al. Cell cycleregulated phosphorylation of p220NPAT by cyclin ...