目的:通过构建小鼠4T1乳腺癌细胞移植瘤Balb/c小鼠模型,探讨黄芪注射液对移植瘤Cyclin1,Bcl-2及Caspase-3蛋白表达的影响.方法:体外培养小鼠乳腺癌4T1细胞,注射接种于Balb/c小鼠右侧腹股沟皮下构建乳腺癌移植瘤模型.50只成瘤小鼠随机分为模型对照组,黄芪注射液2. 60 g/kg,5. 20 g/kg,10. 40 g/kg组和...
4 g/kg组,顺铂组移植瘤组织Cyclin D1阳性区域吸光度值显著降低,Cyclin D1,Bcl-2蛋白水平明显下调,而Cleaved caspase-3蛋白水平显著上调(P <0. 05或P <0. 01).结论:黄芪注射液对小鼠4T1乳腺癌细胞移植瘤生长有显著抑制作用,其机制与黄芪注射液下调Cyclin D1蛋白表达,促进肿瘤细胞凋亡,抑制肿瘤细胞增殖有关....
进一步的研究直接显示出那 GL3.1 dephosphorylates 它的底层, Cyclin-T1; 3,它很少仅仅在植物被学习了.Cyclin-T1 的 downregulation; 3 在更短的谷物导致了米饭,它在房间周期规定为 Cyclin-T 显示新奇功能.我们的调查结果为通过影响 Cyclin-T1 的 phosphorylation 的新奇调停磷酸酶的进程被驾驶的谷物尺寸和产量的...
We found that MLL-AF4, MLL-AF5q31, MLL-ENL and MLL-AF9 each associate with wild type AF4 complex components, including CDK9 and Cyclin T1. In contrast, MLL-AF6 does not associate with any of the AF4 complex components. We propose that the four nuclear MLL translocation partner ...
Cdt1Cul4cyclin D1P287Acyclin D1T286Agenomic instabilityp53rereplicationDeregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent oncogenes in vitro and in vivo, the mechanisms ...