The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which ...
Spy1 is a novel 'cyclin-like' activator of the G1/S transition capable of enhancing cell proliferation as well as inhibiting apoptosis. Spy1 protein levels are tightly regulated during normal mammary development and forced overexpression in mammary mouse models accelerates mammary tumorigenesis. Methods...
1997. A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol. Cell. Biol. 17: 1212–1223. PubMed Google Scholar Meskiene, I., Bogre, L., Dahl, M., Pirck, M., Ha, D.T.C., Swoboda, I., Heberle-Bors, E., Ammerer, G. and Hirt, H. ...
Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors. 包装清单: 产品编号 产品名称 包装 AF1183 Cyclin D1 Rabbit Monoclonal Antibody 50μl AZ050 Western一抗稀释液 50ml - ...
Neither the amount nor the phosphorylation state changed over the course of the cell cycle, in agreement with results reported for CDK5 family members in other systems. Conclusions. We conclude we have probably isolated a dinoflagellate CDK5-like protein. The data reported here support the ...
In S phase, CDK1 in complex with cyclin A2 increases FA size and stress fibre formation by phosphorylating formin-like protein 2 (FMNL2) and probably other FA and actin-associated proteins15,16. By contrast, in G2 phase, CDK1 is inactivated, which leads to a decrease in FA ...
Cancer commonly hijacks key developmental pathways during tumorigenesis and thus frequently exhibits unique properties such as stem cell- like and dedifferentiated states [48], which may underlie the preferential therapeutic benefit conferred by targeting Taspase1 to treat cancers. Primitive Taspase1 ...
kinase domain, CDKs belong to the CMGC group of kinases (named for the initials of some members), along with mitogen- activated protein kinases (MAPKs), glycogen synthase kinase-3 beta (Gsk3β), members of the dual-specificity tyrosine-regulated kinase (DYRK) family and CDK-like kinases [...
Wang G, Kong H, Sun Y, Zhang X, Zhang W, Altman N, de Pamphilis CW, Ma H (2004) Genome-wide analysis of the cyclin family in Arabidopsis and comparative phylogenetic analysis of plant cyclin-like proteins. Plant Physiol 135:1084–1099 Article PubMed CAS Google Scholar Download reference...
Like the full length p16 protein, the p16 peptide does not inhibit cyclin E dependent cdk2 kinase activity in vitro. These data suggest that acute ... E.J. Corey,S Lin - 《Journal of the American Chemical Society》 被引量: 794发表: 1996年 Defects in TGF-beta signaling overcome senescenc...