Our results showed that the cyclin-like F-box domain (FBDC) formed the functional cluster with the lowest P-value. We also observed a significant expansion of FBDC families in V. volvacea. Among these, the FBDC3 family displayed the maximal gene expansion in V. volvacea. Gene expression ...
周期素E抗体Cyclin E1研究领域:肿瘤,心血管, 细胞生物,免疫学,发育生物学,染色质和核信号,微生物学,细胞凋亡,信号转导,干细胞,神经生物学,生长因子和激素,糖尿病,内分泌病,转运蛋白,植物,细菌及病毒, 转录调节因子,海洋生物,上皮细胞, 趋化因子, 结合蛋白 ,细胞表面分子 ,G蛋白偶联受体, 胶原蛋白,糖蛋白,...
(Fig. 2). Following the cyclin box, a region with low sequence conservation with the cyclin box can nevertheless fold into the same three-dimensional structure to form a second cyclin box fold. A similar cyclin box fold can be found in diverse proteins like the transcriptional factor TFIIB ...
Like its yeast ortholog, Cdk1 is the only CDK essential for the cell cycle in mammals [9], whereas both Cdk2 and Cdk3 are dispensable [3,10]. Although Pho85 is not essential in yeast, this kinase is required for viability in some Box 1. The cyclin family Cyclins are a large family...
The activity of Cdc25-like proteins is a rate-limiting step in Drosophila cell cycles as the string and twine phosphatases derepress the Cyclin-dependent kinase Cdk1 to initiate the G2/M transition. Surprisingly, overexpression of string causes cysts to form with only eight cystocytes, in ...
MSA-like sequences are also found in the promoters of G2/M-specific genes encoding kinesin-like proteins, suggesting that a defined set of G2/M-specific genes are co-regulated by a common MSA-mediated mechanism in plants. Thus, the molecular mechanisms regulating B-type cyclin gene ...
2b, c). The latter is as close to switch-like behaviour (an all-or-nothing response to a small change in regulator activity) as can be expected given the spatial metachronicity of mitotic entry in early Xenopus embryos39,40. Therefore, any differences in affinities of CDKs for substrates...
The amino acid sequence deduced for this gene ( CYC 1) shares structural homology with A- and B-type CYCs of other organisms, including a motif, the destruction box, which has been related to the rapid turnover of these CYC proteins in mitosis. When expressed in fission yeast, CYC 1 ...
www.nature.com/scientificreports OPEN received: 29 June 2016 accepted: 16 November 2016 Published: 23 January 2017 Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation Chengcheng Liu, Xiaoyan Zhai, Bin Zhao,Yanfei Wang & ...
Amino acid variants of a protein of the invention may readily be made using peptide synthetic techniques well known in the art, such as solid phase peptide synthesis and the like, or by recombinant DNA manipulations. The manipulation of DNA sequences to produce variant proteins which manifest as...