RB先被Cyclin D-CDK4/6部分磷酸化,导致转录因子E2F释放并上调其靶标。在E2F上游靶标中,有两个E型细胞周期蛋白(Cyclin E1/2),它们结合并激活CDK2。后RB被Cyclin E-CDK2完全磷酸化,从而释放E2F转录程序并导致细胞进入S期所需的蛋白质的合成。 图2:RB和E2F参与G1期调控(图源参考文献2) 2.S期 多种蛋白(ORCs...
Caldon CE, Musgrove EA. Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer. Cell Div 2010;5:2.Caldon CE, Musgrove EA. Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer. Cell Div. 2010; 5:2. [PubMed: 20180967]...
Cyclin E1 and cyclin E2 can associate with and activate CDK2 (1). Upon DNA damage, upregulation/activation of the CDK inhibitors p21 Waf1/Cip1 and p27 Kip1 prevent cyclin E/CDK2 activation, resulting in G1/S arrest. When conditions are favorable for cell cycle progression, cyclin D/CDK...
G1期收到有丝分裂信号后,D型细胞周期蛋白(Cyclin D1/2/3)上调,Cyclin D结合并激活催化伙伴CDK4/6。在G1期,Cyclin D-CDK4/6和Cyclin E-CDK2磷酸化RB…
为解决卵巢癌治疗难题,东京大学的研究人员开展了关于 PLK1 和 WEE1 抑制剂治疗卵巢癌的研究,发现 Cyclin E1 过表达可预测抑制剂疗效,为卵巢癌个性化治疗提供策略。
Cyclin E1 (D7T3U) Rabbit mAb recognizes endogenous levels of total cyclin E1 protein. Based on the sequence of the peptide antigen, this antibody is expected to detect all isoforms of cyclin E1. This antibody does not cross-react with cyclin E2. Species Reactivity: Human, Mouse, Rat Source...
本公司生产销售试剂盒 试剂盒,提供试剂盒专业参数,试剂盒价格,市场行情,优质商品批发,供应厂家等信息.试剂盒 试剂盒 品牌睿创生物|产地上海|价格782.00元|产品规格96T/48T|储存条件2-8℃|检测指标细胞周期素E1|指标缩写ANNA-1;Hu|产品名称人细胞周期素E1(Cyclin-E1)ELISA试
Proteintech's Rabbit Polyclonal Cyclin E2 antibody is validated in IHC, IF/ICC, FC (Intra), IP, Indirect ELISA and shows reactivity with human, mouse samples.
Whereas cyclin E1 is expressed in most proliferating normal and tumor cells, cyclin E2 levels are low or undetectable in nontransformed cells, and are elevated in tumor-derived cells. 实验方案 Product Specific Protocols IHC protocol for Cyclin E2 antibody 11935-1-AP Download protocol IF protocol ...