This has led to intensive study to ascertain whether cyclin D1 is a biological marker in breast cancer; however, the clinical work has produced unexpected results. Work in cell lines and in transgenic mice indicate that CCND1 is a weak oncogene and it was expected that, like c- erbB -2,...
Cyclin D1 protein plays an important part in regulating the progress of the cell during the G1 phase of the cell cycle. The cyclin D1 gene, CCND1, is ampli
[28]Osman I,Scher H,Zhang ZF,et al.Expression of cyclin D1,but not cyclin E and A,is related to progression in billharzial bladder cancer〔J〕.Clin Cancer Res,1997,3:2247 [29]Arber N,Doki Y,Han EKH,et al.Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon...
CyclinD1过量表达可提示食管癌的发生 摘要:Cyclin D1阳性的巴雷特食管(Barrett’s esophagus)患者发生 食管癌 的危险性较高。 (J Natl Cancer Inst 2000;92:1282-1283,1316-1321) Cyclin D1阳性的巴雷特食管(Barretts esophagus)患者发生食管癌的危险性较高。 利兹大学(University of Leeds)的Christopher P. Wild...
p53 inhibits adriamycin-induced down-regulation of cyclin D1 expression in human cancer cells[J]. Biochem Biophys Res Commun, 2002, 290(3): 1101-1107. 1. 申洪, 陆药丹. 免疫组织化学染色的定量方法研究[J]. 生物医学工程学杂志, 1993, 10(3): 281-284. 2. 申洪. 免疫组织显色反应强度...
其中细胞周期素D1(CyclinD1)和细胞周期素 依赖蛋白激酶4(Cyclin—dependent kinase 4,CDK4)与癌变的关系 十分密切,目前已在人类多种肿瘤中发现其蛋白质过表达。 CyclinDl是细胞周期索家族中的主要成员,基因定位于染色 体11q13,调控细胞周期由G1进入S期。人类恶性肿瘤中,常常 出现CyclinDl细胞周期调控蛋白的异常...
This has led to intensive study to ascertain whether cyclin D1 is a biological marker in breast cancer; however, the clinical work has produced unexpected results. Work in cell lines and in transgenic mice indicate that CCND1 is a weak oncogene and it was expected that, like c- erbB -2,...
1 Hunter T, Pines J. Cyclins and cancer Ⅱ: cyclin D and CDK inhibitors come of age. Cell,1994,79:573-582. 2 Donnellan R, Chetty R. Cyclin D1 and human neoplasia. J Clin Pathol: Mol Part,1998,51:1-7. 3 Nakamura S, Yatabe Y, Kurado H, et al. Immunostaining of PRAD-1/cyclin...
cyclin D1作为细胞周期调节因子之一,其过度表达是多种人类原发性肿瘤的特征,对肿瘤的诊断和预后判断具有重要意义。 一、正常细胞周期调控 细胞周期分为G1、S、G2和M 4阶段,由3类因子进行精密调控,它们分别是周期素依赖性激酶(cyclin-dependent kinases,CDKs)、周期素(cyclins)和周期素依赖性激酶抑制因子(cyclin-...
Cyclin D1, a G1 cyclin, has been implicated in the oncogenesis of various types of malignancies via deregulation of cell cycles. Amplification of cyclin D1 as a part of 11q13 amplicon has been reported in lung cancer as well as a subset of carcinomas arising from various organs including...