The structural modeling of peptides can be a useful aid in the discovery of new drugs and a deeper understanding of the molecular mechanisms of life. Here we present a novel multiscale protocol for the structure prediction of linear and cyclic peptides. The protocol combines two main stages: ...
cyclic peptide (redirected fromCyclic peptides) cy·clic pep·tide a peptide that forms a ring structure; for example, tyrocidin A, an antibiotic, is a cyclic decapeptide; valinomycin is a cyclic depsipeptide. Farlex Partner Medical Dictionary © Farlex 2012 ...
In recent years, cyclic peptides have emerged as a promising therapeutic modality due to their diverse biological activities. Understanding the structures of these cyclic peptides and their complexes is crucial for unlocking invaluable insights about protein target–cyclic peptide interaction, which can ...
Disclosed herein is a process for preparing cyclic peptides and peptide annular conformation splicing intermediates. 该方法利用了断裂内含肽催化含有插入在断裂内含肽两部分之间的靶肽的前体肽,形成环化肽的反式剪接能力. The method utilizes a precursor peptide containing the catalytic breaking intein interposed...
The two different forms of the peptide structure was studied using theoretical secondary structure prediction, optical spectroscopic methods (CD, FTIR, Raman) and molecular modelling studies. Our results are discussed and correlated in term of structure-function and/or structure activity relationships....
Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied orally because they are
silico analysis using the algorithm (D2p2)46identified several IDRs within EPAC1, especially within its catalytic (C-terminal) and regulatory (N-terminal) domains. When overlapped to the structure of EPAC1 (Fig.3a) most of the predicted IDRs were found between folded domains, a topology that ...
elongatusBP-1 proteins. The search criteria allowed for one missed cleavage of trypsin, oxidation of methionine, and 6-ppm and 0.1-Da mass accuracies for MS and MS/MS modes, respectively. The decoy database searches were also performed in parallel, and peptides <1% false discovery rate ...
4c). To do this, TdcA1-177 was fused between the LacZ segments that otherwise correspond to the α-peptide (LacZ1-92) and the Ω-fragment (or α-acceptor) of β-galactosidase, resulting in a temperature-sensitive enzyme that we named “thermo-gal.” This chimeric enzyme displayed ...
Provided are cyclic prodrugs of biologically active peptides and peptide nucleic acids exhibiting improved cell membrane permeability and enzymatic stability, containing 3-(2'-hydroxy-4',6'-dimethyl p