总之，本研究发现了限制cGAS对自身基因组DNA活性的新的自卫机制，在核膜屏障丧失后，胞质中cGAS聚集到核周染色质中，而BAF可以竞争性和DNA结合，从而抑制cGAS激活，表明调控核DNA的识别不仅仅只需要简单的空间阻隔，需要更复杂的调控手段。制版人：十一 参考文献 1. Sun, L., et al., Cyclic GMP-AMP synthase is...
Cyclic GMP-AMP synthase (cGAS), as a cytosolic DNA sensor, plays a crucial role inantiviral immunity, and its overactivation induces excessinflammationand tissue damage. Macrophage polarization is critically involved in inflammation; however, the role of cGAS in macrophage polarization during inflammation...
Cyclic GMP-AMP synthase (cGAS) is a major cytosolic DNA sensor that plays a significant role in innate immunity. Upon binding to double stranded DNA (dsDNA), cGAS utilizes GTP and ATP to synthesize the second messenger cyclic GMP-AMP (cGAMP). The cGAMP then binds to the adapter protein sti...
Cyclic GMP-AMP synthase (cGAS) is a major cytosolic DNA sensor that plays a significant role in innate immunity. Upon binding to double stranded DNA (dsDNA), cGAS utilizes GTP and ATP to synthesize the second messenger cyclic GMP-AMP (cGAMP). The cGAMP then binds to the adapter protein sti...
Cyclic GMP-AMP Synthase | 环磷酸鸟苷-磷酸腺苷合成酶 | 抑制剂 | MCE环 GMP-AMP 合酶 (cGAS) 是一种胞质 DNA 传感器,可激活 I 型干扰素反应。 cGAS 与微生物 DNA 以及侵入细胞质的自身 DNA 结合,并催化 cGAMP 合成。然后,cGAMP 作为第二信使结合并激活内质网蛋白 S
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 2013;341:903-6.Gao D, Wu J, Wu YT, Du F, Aroh C, Yan N, Sun L, Chen ZJ. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Sci- ...
The cyclic GMP–AMP synthase (cGAS)–STING pathway is a central component of the cell-autonomous innate immune system in animals1,2. The cGAS protein is a sensor of cytosolic viral DNA and, upon sensing DNA, it produces a cyclic GMP–AMP (cGAMP) signalli
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that activates type 1 IFN response via cGAS/cGAMP/STING-dependent pathway to defend against viral and bacterial infections. The role of c-GAS in adaptive immunity is completely unknown. In this study, we attempted to determine whether cG...
Cyclic GMP-AMP Synthase (cGAS) is a cytosolic DNA sensor that activates type I interferon pathway by generating a second messenger (P1346) 来自 semanticscholar 喜欢 0 阅读量: 84 作者:L Sun,J Wu,Z Chen 摘要: The presence of DNA in the cytoplasm of mammalian cells is a danger signal ...
In the body, cells have DNA sensors called cyclic GMP-AMP synthase (cGAS), which recognize foreign DNA in the cytoplasm and trigger the production of cyclic dinucleotides (CDNs). William A. Haseltine, Forbes, 26 Apr. 2022 Word History Etymology guanosine + mon- + phosphate First Known Us...