总之，本研究发现了限制cGAS对自身基因组DNA活性的新的自卫机制，在核膜屏障丧失后，胞质中cGAS聚集到核周染色质中，而BAF可以竞争性和DNA结合，从而抑制cGAS激活，表明调控核DNA的识别不仅仅只需要简单的空间阻隔，需要更复杂的调控手段。制版人：十一 参考文献 1. Sun, L., et al., Cyclic GMP-AMP synthase is...
Cyclic GMP-AMP synthase (cGAS), as a cytosolic DNA sensor, plays a crucial role in antiviral immunity, and its overactivation induces excess inflammation and tissue damage. Macrophage polarization is critically involved in inflammation; however, the role of cGAS in macrophage polarization during inflam...
Cyclic GMP-AMP synthase (cGAS) is a major cytosolic DNA sensor that plays a significant role in innate immunity. Upon binding to double stranded DNA (dsDNA), cGAS utilizes GTP and ATP to synthesize the second messenger cyclic GMP-AMP (cGAMP). The cGAMP then binds to the adapter protein ...
cGAS 在自噬的调节中也发挥着重要作用;这表明炎症反应和自噬之间存在密切的分子和信号传导联系。更多详情参考:https://www.medchemexpress.cn/Targets/cyclic-gmp-amp-synthase.html Cyclic GMP-AMP Synthase | 环磷酸鸟苷-磷酸腺苷合成酶 | 抑制剂 | MCE由MedChemExpress (MCE) 为您提供,如您想了解更多关于...
Cyclic GMP-AMP synthase (cGAS) is a major cytosolic DNA sensor that plays a significant role in innate immunity. Upon binding to double stranded DNA (dsDNA), cGAS utilizes GTP and ATP to synthesize the second messenger cyclic GMP-AMP (cGAMP). The cGAMP then binds to the adapter protein sti...
产品活性:G150 是一种高选择性的 human cyclic GMP-AMP synthase h-cGAS 抑制剂 IC50 值为 10.2 nM。G150 可抑制 dsDNA 引发的干扰素表达,可用于炎症的研究。 生物活性:G150 是一种高度选择性的人环 GMP-AMP 合酶 (h-cGAS)抑制剂,IC50为 10.2 nM。 G150 抑制 dsDNA 触发的干扰素表达,G150 可用于炎症...
The cyclic GMP–AMP synthase (cGAS)–STING pathway is a central component of the cell-autonomous innate immune system in animals1,2. The cGAS protein is a sensor of cytosolic viral DNA and, upon sensing DNA, it produces a cyclic GMP–AMP (cGAMP) signalli
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenge...
细胞内的cGAS-STING信号通路由DNA感受器cGAS(Cyclic GMP-AMP synthase)和其下游效应蛋白STING(Stimulator of interferon genes)组成,在细胞抵抗外界病原体入侵和肿瘤发生过程中发挥重要功能。通常情况下,cGAS结合双链DNA催化细胞内的GTP和ATP转化成的第二信使2’3’-cyclic-GMP-AMP (cGAMP),并激活内质网上的STING,引...
Because cGAS produces the cyclic dinucleotide cGAMP, and some cyclic dinucleotides such as cyclic di-AMP and cyclic di-GMP can impact bacteria directly (Li and He, 2012, Witte et al., 2013), we tested if cGAMP alone could inhibit M. tuberculosis growth in vitro, and found no effect of ...